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  • 11.0 [archived version]
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MYH11 MYH11 DAZAP1 DAZAP1 NXPH2 NXPH2 SEPT9 SEPT9 SPATA6L SPATA6L OVCA2 OVCA2 DPH1 DPH1 DPH2 DPH2 ZAR1 ZAR1 HIC1 HIC1 HSD17B12 HSD17B12
OVCA2, serine hydrolase domain containing in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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OVCA2OVCA2, serine hydrolase domain containing; Belongs to the LovG family (227 aa)    
Predicted Functional Partners:
DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity); Minor histocompatibility antigens (443 aa)
 
 
   
  0.905
SPATA6L
Spermatogenesis-associated 6-like protein; Spermatogenesis associated 6 like (334 aa)
           
  0.838
DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) (489 aa)
     
   
  0.717
DAZAP1
DAZ-associated protein 1; RNA-binding protein, which may be required during spermatogenesis (407 aa)
           
  0.637
MYH11
Myosin-11; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (1979 aa)
       
 
  0.548
NXPH2
Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors; Belongs to the neurexophilin family (264 aa)
           
  0.548
HSD17B12
Very-long-chain 3-oxoacyl-CoA reductase; Catalyzes the second of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3- ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of memb [...] (312 aa)
           
  0.542
SEPT9
Septin-9; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Septin GTPase family (586 aa)
           
  0.536
HIC1
Hypermethylated in cancer 1 protein; Transcriptional repressor. Recognizes and binds to the consensus sequence ’5-[CG]NG[CG]GGGCA[CA]CC-3’. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In c [...] (733 aa)
           
  0.525
ZAR1
Zygote arrest protein 1; Essential for female fertility. May play a role in the oocyte-to-embryo transition (By similarity); Zinc fingers 3CxxC-type (424 aa)
           
  0.516
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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