node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DAZAP1 | OVCA2 | ENSP00000233078 | ENSP00000461388 | DAZ-associated protein 1; RNA-binding protein, which may be required during spermatogenesis | OVCA2, serine hydrolase domain containing; Belongs to the LovG family | 0.637 |
DAZAP1 | SPATA6L | ENSP00000233078 | ENSP00000417063 | DAZ-associated protein 1; RNA-binding protein, which may be required during spermatogenesis | Spermatogenesis-associated 6-like protein; Spermatogenesis associated 6 like | 0.731 |
DPH1 | DPH2 | ENSP00000263083 | ENSP00000255108 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity); Minor histocompatibility antigens | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) | 0.998 |
DPH1 | HIC1 | ENSP00000263083 | ENSP00000314080 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity); Minor histocompatibility antigens | Hypermethylated in cancer 1 protein; Transcriptional repressor. Recognizes and binds to the consensus sequence ’5-[CG]NG[CG]GGGCA[CA]CC-3’. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In c [...] | 0.474 |
DPH1 | NXPH2 | ENSP00000263083 | ENSP00000272641 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity); Minor histocompatibility antigens | Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors; Belongs to the neurexophilin family | 0.522 |
DPH1 | OVCA2 | ENSP00000263083 | ENSP00000461388 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity); Minor histocompatibility antigens | OVCA2, serine hydrolase domain containing; Belongs to the LovG family | 0.905 |
DPH1 | SEPT9 | ENSP00000263083 | ENSP00000391249 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity); Minor histocompatibility antigens | Septin-9; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Septin GTPase family | 0.510 |
DPH2 | DPH1 | ENSP00000255108 | ENSP00000263083 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity); Minor histocompatibility antigens | 0.998 |
DPH2 | OVCA2 | ENSP00000255108 | ENSP00000461388 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) | OVCA2, serine hydrolase domain containing; Belongs to the LovG family | 0.717 |
HIC1 | DPH1 | ENSP00000314080 | ENSP00000263083 | Hypermethylated in cancer 1 protein; Transcriptional repressor. Recognizes and binds to the consensus sequence ’5-[CG]NG[CG]GGGCA[CA]CC-3’. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In c [...] | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity); Minor histocompatibility antigens | 0.474 |
HIC1 | OVCA2 | ENSP00000314080 | ENSP00000461388 | Hypermethylated in cancer 1 protein; Transcriptional repressor. Recognizes and binds to the consensus sequence ’5-[CG]NG[CG]GGGCA[CA]CC-3’. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In c [...] | OVCA2, serine hydrolase domain containing; Belongs to the LovG family | 0.525 |
HSD17B12 | OVCA2 | ENSP00000278353 | ENSP00000461388 | Very-long-chain 3-oxoacyl-CoA reductase; Catalyzes the second of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3- ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of memb [...] | OVCA2, serine hydrolase domain containing; Belongs to the LovG family | 0.542 |
HSD17B12 | ZAR1 | ENSP00000278353 | ENSP00000329803 | Very-long-chain 3-oxoacyl-CoA reductase; Catalyzes the second of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3- ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of memb [...] | Zygote arrest protein 1; Essential for female fertility. May play a role in the oocyte-to-embryo transition (By similarity); Zinc fingers 3CxxC-type | 0.403 |
MYH11 | OVCA2 | ENSP00000379616 | ENSP00000461388 | Myosin-11; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | OVCA2, serine hydrolase domain containing; Belongs to the LovG family | 0.548 |
NXPH2 | DPH1 | ENSP00000272641 | ENSP00000263083 | Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors; Belongs to the neurexophilin family | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity); Minor histocompatibility antigens | 0.522 |
NXPH2 | OVCA2 | ENSP00000272641 | ENSP00000461388 | Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors; Belongs to the neurexophilin family | OVCA2, serine hydrolase domain containing; Belongs to the LovG family | 0.548 |
NXPH2 | SEPT9 | ENSP00000272641 | ENSP00000391249 | Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors; Belongs to the neurexophilin family | Septin-9; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Septin GTPase family | 0.499 |
OVCA2 | DAZAP1 | ENSP00000461388 | ENSP00000233078 | OVCA2, serine hydrolase domain containing; Belongs to the LovG family | DAZ-associated protein 1; RNA-binding protein, which may be required during spermatogenesis | 0.637 |
OVCA2 | DPH1 | ENSP00000461388 | ENSP00000263083 | OVCA2, serine hydrolase domain containing; Belongs to the LovG family | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity); Minor histocompatibility antigens | 0.905 |
OVCA2 | DPH2 | ENSP00000461388 | ENSP00000255108 | OVCA2, serine hydrolase domain containing; Belongs to the LovG family | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) | 0.717 |