| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD52 | C15orf26 | ENSP00000267116 | ENSP00000286732 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates; Ankyrin repeat domain containing | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly | 0.504 |
| ANKRD52 | LYSMD3 | ENSP00000267116 | ENSP00000314518 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates; Ankyrin repeat domain containing | LysM and putative peptidoglycan-binding domain-containing protein 3; LysM domain containing 3 | 0.449 |
| ANKRD52 | MYCBPAP | ENSP00000267116 | ENSP00000323184 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates; Ankyrin repeat domain containing | MYCBP-associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity) | 0.503 |
| ANKRD52 | WSCD1 | ENSP00000267116 | ENSP00000460825 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates; Ankyrin repeat domain containing | WSC domain containing 1 | 0.565 |
| B3GALT6 | WSCD1 | ENSP00000368496 | ENSP00000460825 | Beta-1,3-galactosyltransferase 6; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues | WSC domain containing 1 | 0.502 |
| C15orf26 | ANKRD52 | ENSP00000286732 | ENSP00000267116 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates; Ankyrin repeat domain containing | 0.504 |
| C15orf26 | LYSMD3 | ENSP00000286732 | ENSP00000314518 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly | LysM and putative peptidoglycan-binding domain-containing protein 3; LysM domain containing 3 | 0.505 |
| C15orf26 | MYCBPAP | ENSP00000286732 | ENSP00000323184 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly | MYCBP-associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity) | 0.530 |
| C15orf26 | WSCD1 | ENSP00000286732 | ENSP00000460825 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly | WSC domain containing 1 | 0.623 |
| C16orf45 | CACNG4 | ENSP00000300006 | ENSP00000262138 | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | Voltage-dependent calcium channel gamma-4 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state | 0.468 |
| C16orf45 | DENND1B | ENSP00000300006 | ENSP00000479816 | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | DENN domain-containing protein 1B; Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Plays a role in clathrin- mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes- acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregul [...] | 0.468 |
| C16orf45 | SGSM1 | ENSP00000300006 | ENSP00000383212 | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | Small G protein signaling modulator 1; Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B; Belongs to the RUTBC family | 0.492 |
| C16orf45 | TSEN54 | ENSP00000300006 | ENSP00000327487 | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | tRNA-splicing endonuclease subunit Sen54; Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5’ and 3’ splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2’,3’ cyclic phosphate and 5’-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA bo [...] | 0.468 |
| C16orf45 | WSCD1 | ENSP00000300006 | ENSP00000460825 | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | WSC domain containing 1 | 0.596 |
| CACNG4 | C16orf45 | ENSP00000262138 | ENSP00000300006 | Voltage-dependent calcium channel gamma-4 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | 0.468 |
| CACNG4 | DENND1B | ENSP00000262138 | ENSP00000479816 | Voltage-dependent calcium channel gamma-4 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state | DENN domain-containing protein 1B; Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Plays a role in clathrin- mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes- acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregul [...] | 0.428 |
| CACNG4 | WSCD1 | ENSP00000262138 | ENSP00000460825 | Voltage-dependent calcium channel gamma-4 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state | WSC domain containing 1 | 0.502 |
| DENND1B | C16orf45 | ENSP00000479816 | ENSP00000300006 | DENN domain-containing protein 1B; Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Plays a role in clathrin- mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes- acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregul [...] | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | 0.468 |
| DENND1B | CACNG4 | ENSP00000479816 | ENSP00000262138 | DENN domain-containing protein 1B; Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Plays a role in clathrin- mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes- acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregul [...] | Voltage-dependent calcium channel gamma-4 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state | 0.428 |
| DENND1B | WSCD1 | ENSP00000479816 | ENSP00000460825 | DENN domain-containing protein 1B; Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Plays a role in clathrin- mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes- acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregul [...] | WSC domain containing 1 | 0.511 |
