| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASPA | SHPK | ENSP00000263080 | ENSP00000225519 | Aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism | 0.796 |
| ASPA | SPATA22 | ENSP00000263080 | ENSP00000459580 | Aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | 0.548 |
| BTBD16 | SPATA22 | ENSP00000260723 | ENSP00000459580 | BTB/POZ domain-containing protein 16; BTB domain containing 16 | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | 0.550 |
| CFAP43 | SPATA22 | ENSP00000349568 | ENSP00000459580 | Cilia and flagella associated protein 43; Belongs to the CFAP43 family | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | 0.531 |
| IRG1 | SPATA22 | ENSP00000366682 | ENSP00000459580 | Cis-aconitate decarboxylase; Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)- mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1- mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | 0.518 |
| MEIOB | RAD54B | ENSP00000390778 | ENSP00000336606 | Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3’-5’ exonuclease activity i [...] | DNA repair and recombination protein RAD54B; Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group; Belongs to the SNF2/RAD54 helicase family | 0.547 |
| MEIOB | SPATA22 | ENSP00000390778 | ENSP00000459580 | Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3’-5’ exonuclease activity i [...] | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | 0.819 |
| MEIOB | SYCP3 | ENSP00000390778 | ENSP00000376658 | Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3’-5’ exonuclease activity i [...] | Synaptonemal complex protein 3; Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity). Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity); Belongs to the XLR/SYCP3 family | 0.488 |
| MND1 | RAD54B | ENSP00000240488 | ENSP00000336606 | Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks | DNA repair and recombination protein RAD54B; Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group; Belongs to the SNF2/RAD54 helicase family | 0.727 |
| MND1 | SPATA22 | ENSP00000240488 | ENSP00000459580 | Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | 0.565 |
| RAD54B | MEIOB | ENSP00000336606 | ENSP00000390778 | DNA repair and recombination protein RAD54B; Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group; Belongs to the SNF2/RAD54 helicase family | Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3’-5’ exonuclease activity i [...] | 0.547 |
| RAD54B | MND1 | ENSP00000336606 | ENSP00000240488 | DNA repair and recombination protein RAD54B; Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group; Belongs to the SNF2/RAD54 helicase family | Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks | 0.727 |
| RAD54B | SPATA22 | ENSP00000336606 | ENSP00000459580 | DNA repair and recombination protein RAD54B; Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group; Belongs to the SNF2/RAD54 helicase family | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | 0.674 |
| SHPK | ASPA | ENSP00000225519 | ENSP00000263080 | Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism | Aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | 0.796 |
| SHPK | SPATA22 | ENSP00000225519 | ENSP00000459580 | Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | 0.616 |
| SPATA22 | ASPA | ENSP00000459580 | ENSP00000263080 | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | Aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | 0.548 |
| SPATA22 | BTBD16 | ENSP00000459580 | ENSP00000260723 | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | BTB/POZ domain-containing protein 16; BTB domain containing 16 | 0.550 |
| SPATA22 | CFAP43 | ENSP00000459580 | ENSP00000349568 | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | Cilia and flagella associated protein 43; Belongs to the CFAP43 family | 0.531 |
| SPATA22 | IRG1 | ENSP00000459580 | ENSP00000366682 | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | Cis-aconitate decarboxylase; Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)- mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1- mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation | 0.518 |
| SPATA22 | MEIOB | ENSP00000459580 | ENSP00000390778 | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3’-5’ exonuclease activity i [...] | 0.819 |
