LRRC37A2 protein (human) - STRING database

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LRRC37A2

Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2 (1700 aa)

Predicted Functional Partners:

PRSS45

0.689

LPHN3

0.685

LPHN1

0.685

LPHN2

0.685

DCAKD

0.668

RIT2

0.519

ARL17B

0.502

DGKQ

0.476

MEIS3

0.413

NOTCH2NL

0.406

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL17B	LRRC37A2	ENSP00000404247	ENSP00000459551	ADP-ribosylation factor-like protein 17; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity); ARF GTPase family	Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2	0.502
DCAKD	DGKQ	ENSP00000308515	ENSP00000273814	dephospho-CoA kinase domain containing	Diacylglycerol kinase theta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity	0.508
DCAKD	LRRC37A2	ENSP00000308515	ENSP00000459551	dephospho-CoA kinase domain containing	Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2	0.668
DCAKD	RIT2	ENSP00000308515	ENSP00000321805	dephospho-CoA kinase domain containing	GTP-binding protein Rit2; Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator; RAS type GTPase family	0.516
DGKQ	DCAKD	ENSP00000273814	ENSP00000308515	Diacylglycerol kinase theta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity	dephospho-CoA kinase domain containing	0.508
DGKQ	LRRC37A2	ENSP00000273814	ENSP00000459551	Diacylglycerol kinase theta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity	Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2	0.476
DGKQ	RIT2	ENSP00000273814	ENSP00000321805	Diacylglycerol kinase theta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity	GTP-binding protein Rit2; Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator; RAS type GTPase family	0.566
LPHN1	LRRC37A2	ENSP00000340688	ENSP00000459551	Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity)	Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2	0.685
LPHN2	LRRC37A2	ENSP00000322270	ENSP00000459551	Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily	Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2	0.685
LPHN3	LRRC37A2	ENSP00000422533	ENSP00000459551	Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily	Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2	0.685
LRRC37A2	ARL17B	ENSP00000459551	ENSP00000404247	Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2	ADP-ribosylation factor-like protein 17; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity); ARF GTPase family	0.502
LRRC37A2	DCAKD	ENSP00000459551	ENSP00000308515	Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2	dephospho-CoA kinase domain containing	0.668
LRRC37A2	DGKQ	ENSP00000459551	ENSP00000273814	Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2	Diacylglycerol kinase theta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity	0.476
LRRC37A2	LPHN1	ENSP00000459551	ENSP00000340688	Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2	Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity)	0.685
LRRC37A2	LPHN2	ENSP00000459551	ENSP00000322270	Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2	Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily	0.685
LRRC37A2	LPHN3	ENSP00000459551	ENSP00000422533	Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2	Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily	0.685
LRRC37A2	MEIS3	ENSP00000459551	ENSP00000453307	Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2	Homeobox protein Meis3; TALE class homeoboxes and pseudogenes	0.413
LRRC37A2	NOTCH2NL	ENSP00000459551	ENSP00000464060	Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2	Notch homolog 2 N-terminal-like protein; May function in the Notch signaling pathway and regulate neutrophil differentiation	0.406
LRRC37A2	PRSS45	ENSP00000459551	ENSP00000401932	Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2	Uncharacterized protein; Serine protease 45	0.689
LRRC37A2	RIT2	ENSP00000459551	ENSP00000321805	Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2	GTP-binding protein Rit2; Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator; RAS type GTPase family	0.519

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