node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
API5 | CCDC64B | ENSP00000431391 | ENSP00000459043 | Apoptosis inhibitor 5; Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs; Armadillo-like helical domain containing | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | 0.548 |
BICD1 | BICD2 | ENSP00000281474 | ENSP00000349351 | Protein bicaudal D homolog 1; Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex; Belongs to the BicD family | Protein bicaudal D homolog 2; Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non- processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum [...] | 0.903 |
BICD1 | CCDC64B | ENSP00000281474 | ENSP00000459043 | Protein bicaudal D homolog 1; Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex; Belongs to the BicD family | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | 0.635 |
BICD2 | BICD1 | ENSP00000349351 | ENSP00000281474 | Protein bicaudal D homolog 2; Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non- processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum [...] | Protein bicaudal D homolog 1; Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex; Belongs to the BicD family | 0.903 |
BICD2 | CCDC64B | ENSP00000349351 | ENSP00000459043 | Protein bicaudal D homolog 2; Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non- processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum [...] | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | 0.553 |
BICD2 | RAB11FIP3 | ENSP00000349351 | ENSP00000262305 | Protein bicaudal D homolog 2; Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non- processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum [...] | Rab11 family-interacting protein 3; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an ’address tag’ delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive [...] | 0.509 |
BICD2 | SPDL1 | ENSP00000349351 | ENSP00000265295 | Protein bicaudal D homolog 2; Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non- processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum [...] | Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various [...] | 0.545 |
CCDC64B | API5 | ENSP00000459043 | ENSP00000431391 | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | Apoptosis inhibitor 5; Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs; Armadillo-like helical domain containing | 0.548 |
CCDC64B | BICD1 | ENSP00000459043 | ENSP00000281474 | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | Protein bicaudal D homolog 1; Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex; Belongs to the BicD family | 0.635 |
CCDC64B | BICD2 | ENSP00000459043 | ENSP00000349351 | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | Protein bicaudal D homolog 2; Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non- processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum [...] | 0.553 |
CCDC64B | FAM160A1 | ENSP00000459043 | ENSP00000413196 | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family | 0.576 |
CCDC64B | FAM160A2 | ENSP00000459043 | ENSP00000265978 | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | FTS and Hook-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex); Belongs to the UPF0518 family | 0.518 |
CCDC64B | FAM160B1 | ENSP00000459043 | ENSP00000358251 | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | Protein FAM160B1; Family with sequence similarity 160 member B1; Armadillo-like helical domain containing | 0.481 |
CCDC64B | HOOK1 | ENSP00000459043 | ENSP00000360252 | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) | 0.551 |
CCDC64B | HOOK2 | ENSP00000459043 | ENSP00000380785 | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | Protein Hook homolog 2; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones | 0.589 |
CCDC64B | RAB11FIP3 | ENSP00000459043 | ENSP00000262305 | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | Rab11 family-interacting protein 3; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an ’address tag’ delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive [...] | 0.598 |
CCDC64B | SPDL1 | ENSP00000459043 | ENSP00000265295 | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various [...] | 0.563 |
FAM160A1 | CCDC64B | ENSP00000413196 | ENSP00000459043 | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | 0.576 |
FAM160A1 | HOOK1 | ENSP00000413196 | ENSP00000360252 | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) | 0.543 |
FAM160A2 | CCDC64B | ENSP00000265978 | ENSP00000459043 | FTS and Hook-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex); Belongs to the UPF0518 family | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | 0.518 |