• Version:
  • 11.0 [archived version]
STRINGSTRING
ZNF304 ZNF304 OR52R1 OR52R1 PCDHGA4 PCDHGA4 PPP1R18 PPP1R18 NKPD1 NKPD1 KIAA0513 KIAA0513 LRRC71 LRRC71 KNDC1 KNDC1 XKR4 XKR4
"PCDHGA4" - Protocadherin gamma-A4 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
PCDHGA4Protocadherin gamma-A4; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins (962 aa)    
Predicted Functional Partners:
OR52R1
Olfactory receptor 52R1; Odorant receptor; Olfactory receptors, family 52 (315 aa)
           
  0.669
LRRC71
Leucine-rich repeat-containing protein 71; Leucine rich repeat containing 71 (559 aa)
           
  0.558
KIAA0513
Uncharacterized protein KIAA0513; KIAA0513 (411 aa)
     
   
  0.526
KNDC1
Protein very KIND; RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (1749 aa)
     
   
  0.436
ZNF304
Zinc finger protein 304; Acts as transcriptional regulator and plays a role in gene silencing. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of ’Lys-27’ of histone H3 (H3K27me3) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter re [...] (659 aa)
       
 
  0.426
NKPD1
NTPase KAP family P-loop domain containing 1 (832 aa)
       
 
  0.425
XKR4
XK-related protein 4; XK related family (650 aa)
           
  0.424
PPP1R18
Phostensin; Isoform 1- May target protein phosphatase 1 to F-actin cytoskeleton (613 aa)
           
  0.410
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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