| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BRAT1 | INCA1 | ENSP00000339637 | ENSP00000458316 | BRCA1-associated ATM activator 1; Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Plays a role in regulating mitochondrial function and cell proliferation. Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors | Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family | 0.520 |
| C9orf9 | INCA1 | ENSP00000298546 | ENSP00000458316 | Sperm acrosome-associated protein 9; Chromosome 9 open reading frame 9 | Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family | 0.525 |
| C9orf9 | PROCA1 | ENSP00000298546 | ENSP00000301039 | Sperm acrosome-associated protein 9; Chromosome 9 open reading frame 9 | Protein interacting with cyclin A1; Belongs to the PROCA1 family | 0.522 |
| CCNA1 | CDK2 | ENSP00000255465 | ENSP00000266970 | Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells; Belongs to the cyclin family. Cyclin AB subfamily | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | 0.994 |
| CCNA1 | INCA1 | ENSP00000255465 | ENSP00000458316 | Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells; Belongs to the cyclin family. Cyclin AB subfamily | Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family | 0.666 |
| CCNA1 | KLHDC9 | ENSP00000255465 | ENSP00000356990 | Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells; Belongs to the cyclin family. Cyclin AB subfamily | Kelch domain containing 9 | 0.697 |
| CCNA1 | PROCA1 | ENSP00000255465 | ENSP00000301039 | Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells; Belongs to the cyclin family. Cyclin AB subfamily | Protein interacting with cyclin A1; Belongs to the PROCA1 family | 0.550 |
| CDK2 | CCNA1 | ENSP00000266970 | ENSP00000255465 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells; Belongs to the cyclin family. Cyclin AB subfamily | 0.994 |
| CDK2 | INCA1 | ENSP00000266970 | ENSP00000458316 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family | 0.560 |
| CDK2 | ING5 | ENSP00000266970 | ENSP00000322142 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | Inhibitor of growth protein 5; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator; Belongs to the ING family | 0.602 |
| INCA1 | BRAT1 | ENSP00000458316 | ENSP00000339637 | Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family | BRCA1-associated ATM activator 1; Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Plays a role in regulating mitochondrial function and cell proliferation. Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors | 0.520 |
| INCA1 | C9orf9 | ENSP00000458316 | ENSP00000298546 | Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family | Sperm acrosome-associated protein 9; Chromosome 9 open reading frame 9 | 0.525 |
| INCA1 | CCNA1 | ENSP00000458316 | ENSP00000255465 | Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family | Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells; Belongs to the cyclin family. Cyclin AB subfamily | 0.666 |
| INCA1 | CDK2 | ENSP00000458316 | ENSP00000266970 | Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | 0.560 |
| INCA1 | ING5 | ENSP00000458316 | ENSP00000322142 | Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family | Inhibitor of growth protein 5; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator; Belongs to the ING family | 0.747 |
| INCA1 | KAT6A | ENSP00000458316 | ENSP00000380136 | Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family | Histone acetyltransferase KAT6A; Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at ’Lys-120’ and ’Lys-382’ and controls its transcriptional activity via association with PML; MYST type domain containing lysine acetyltransferases | 0.509 |
| INCA1 | KLHDC9 | ENSP00000458316 | ENSP00000356990 | Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family | Kelch domain containing 9 | 0.589 |
| INCA1 | PROCA1 | ENSP00000458316 | ENSP00000301039 | Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family | Protein interacting with cyclin A1; Belongs to the PROCA1 family | 0.549 |
| INCA1 | TBATA | ENSP00000458316 | ENSP00000299290 | Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family | Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function | 0.644 |
| INCA1 | ZNF16 | ENSP00000458316 | ENSP00000276816 | Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family | Zinc finger protein 16; Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.532 |
