node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARFGEF2 | GOLGA8G | ENSP00000360985 | ENSP00000458130 | Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma [...] | Golgin A8 family member G; Belongs to the GOLGA8 family | 0.490 |
C3orf30 | CYFIP1 | ENSP00000295622 | ENSP00000481038 | Uncharacterized protein C3orf30; Chromosome 3 open reading frame 30 | Cytoplasmic FMR1-interacting protein 1; Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the [...] | 0.420 |
C3orf30 | GOLGA8G | ENSP00000295622 | ENSP00000458130 | Uncharacterized protein C3orf30; Chromosome 3 open reading frame 30 | Golgin A8 family member G; Belongs to the GOLGA8 family | 0.588 |
C3orf30 | NIPA2 | ENSP00000295622 | ENSP00000337618 | Uncharacterized protein C3orf30; Chromosome 3 open reading frame 30 | Magnesium transporter NIPA2; Acts as a selective Mg(2+) transporter; Belongs to the NIPA family | 0.530 |
CYFIP1 | C3orf30 | ENSP00000481038 | ENSP00000295622 | Cytoplasmic FMR1-interacting protein 1; Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the [...] | Uncharacterized protein C3orf30; Chromosome 3 open reading frame 30 | 0.420 |
CYFIP1 | GOLGA8G | ENSP00000481038 | ENSP00000458130 | Cytoplasmic FMR1-interacting protein 1; Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the [...] | Golgin A8 family member G; Belongs to the GOLGA8 family | 0.468 |
CYFIP1 | NIPA2 | ENSP00000481038 | ENSP00000337618 | Cytoplasmic FMR1-interacting protein 1; Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the [...] | Magnesium transporter NIPA2; Acts as a selective Mg(2+) transporter; Belongs to the NIPA family | 0.990 |
GOLGA8G | ARFGEF2 | ENSP00000458130 | ENSP00000360985 | Golgin A8 family member G; Belongs to the GOLGA8 family | Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma [...] | 0.490 |
GOLGA8G | C3orf30 | ENSP00000458130 | ENSP00000295622 | Golgin A8 family member G; Belongs to the GOLGA8 family | Uncharacterized protein C3orf30; Chromosome 3 open reading frame 30 | 0.588 |
GOLGA8G | CYFIP1 | ENSP00000458130 | ENSP00000481038 | Golgin A8 family member G; Belongs to the GOLGA8 family | Cytoplasmic FMR1-interacting protein 1; Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the [...] | 0.468 |
GOLGA8G | GOLGB1 | ENSP00000458130 | ENSP00000377275 | Golgin A8 family member G; Belongs to the GOLGA8 family | Golgin subfamily B member 1; May participate in forming intercisternal cross-bridges of the Golgi complex | 0.416 |
GOLGA8G | GORASP1 | ENSP00000458130 | ENSP00000313869 | Golgin A8 family member G; Belongs to the GOLGA8 family | Golgi reassembly-stacking protein 1; Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity- its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes; PDZ domain containing | 0.400 |
GOLGA8G | GOSR1 | ENSP00000458130 | ENSP00000225724 | Golgin A8 family member G; Belongs to the GOLGA8 family | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an impor [...] | 0.425 |
GOLGA8G | HERC2 | ENSP00000458130 | ENSP00000261609 | Golgin A8 family member G; Belongs to the GOLGA8 family | E3 ubiquitin-protein ligase HERC2; E3 ubiquitin-protein ligase that regulates ubiquitin- dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of ’Lys-63’-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscill [...] | 0.565 |
GOLGA8G | NIPA2 | ENSP00000458130 | ENSP00000337618 | Golgin A8 family member G; Belongs to the GOLGA8 family | Magnesium transporter NIPA2; Acts as a selective Mg(2+) transporter; Belongs to the NIPA family | 0.560 |
GOLGA8G | STX5 | ENSP00000458130 | ENSP00000294179 | Golgin A8 family member G; Belongs to the GOLGA8 family | Syntaxin-5; Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus; Syntaxins | 0.425 |
GOLGA8G | USO1 | ENSP00000458130 | ENSP00000444850 | Golgin A8 family member G; Belongs to the GOLGA8 family | General vesicular transport factor p115; General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity; Armadillo-like helical domain containing | 0.423 |
GOLGB1 | GOLGA8G | ENSP00000377275 | ENSP00000458130 | Golgin subfamily B member 1; May participate in forming intercisternal cross-bridges of the Golgi complex | Golgin A8 family member G; Belongs to the GOLGA8 family | 0.416 |
GOLGB1 | GORASP1 | ENSP00000377275 | ENSP00000313869 | Golgin subfamily B member 1; May participate in forming intercisternal cross-bridges of the Golgi complex | Golgi reassembly-stacking protein 1; Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity- its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes; PDZ domain containing | 0.976 |
GOLGB1 | GOSR1 | ENSP00000377275 | ENSP00000225724 | Golgin subfamily B member 1; May participate in forming intercisternal cross-bridges of the Golgi complex | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an impor [...] | 0.988 |