SMIM1 protein (human) - STRING database

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SMIM1

Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family (78 aa)

Predicted Functional Partners:

ATP6AP1L

0.746

EFCAB8

0.497

MARCH5

0.464

SLC25A40

0.461

CDKN1A

0.449

DUSP22

0.447

FYB

0.443

RPLP2

0.440

WRB

0.418

MALL

0.405

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP6AP1L	SMIM1	ENSP00000369513	ENSP00000457386	V-type proton ATPase subunit S1-like protein; ATPase H+ transporting accessory protein 1 like	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	0.746
CDKN1A	SMIM1	ENSP00000384849	ENSP00000457386	Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 fo [...]	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	0.449
DUSP22	SMIM1	ENSP00000397459	ENSP00000457386	Dual specificity protein phosphatase 22; Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK) (By similarity); Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	0.447
EFCAB8	SMIM1	ENSP00000383366	ENSP00000457386	EF-hand calcium-binding domain-containing protein 8; EF-hand calcium binding domain 8	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	0.497
FYB	SMIM1	ENSP00000427114	ENSP00000457386	FYN-binding protein 1; Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	0.443
MALL	SMIM1	ENSP00000272462	ENSP00000457386	MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	0.405
MARCH5	SMIM1	ENSP00000351813	ENSP00000457386	E3 ubiquitin-protein ligase MARCH5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1; Membrane associated ring-CH-type fingers	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	0.464
RPLP2	SMIM1	ENSP00000322419	ENSP00000457386	60S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis; L ribosomal proteins	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	0.440
SLC25A40	SMIM1	ENSP00000344831	ENSP00000457386	Solute carrier family 25 member 40	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	0.461
SMIM1	ATP6AP1L	ENSP00000457386	ENSP00000369513	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	V-type proton ATPase subunit S1-like protein; ATPase H+ transporting accessory protein 1 like	0.746
SMIM1	CDKN1A	ENSP00000457386	ENSP00000384849	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 fo [...]	0.449
SMIM1	DUSP22	ENSP00000457386	ENSP00000397459	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	Dual specificity protein phosphatase 22; Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK) (By similarity); Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily	0.447
SMIM1	EFCAB8	ENSP00000457386	ENSP00000383366	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	EF-hand calcium-binding domain-containing protein 8; EF-hand calcium binding domain 8	0.497
SMIM1	FYB	ENSP00000457386	ENSP00000427114	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	FYN-binding protein 1; Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton	0.443
SMIM1	MALL	ENSP00000457386	ENSP00000272462	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family	0.405
SMIM1	MARCH5	ENSP00000457386	ENSP00000351813	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	E3 ubiquitin-protein ligase MARCH5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1; Membrane associated ring-CH-type fingers	0.464
SMIM1	RPLP2	ENSP00000457386	ENSP00000322419	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	60S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis; L ribosomal proteins	0.440
SMIM1	SLC25A40	ENSP00000457386	ENSP00000344831	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	Solute carrier family 25 member 40	0.461
SMIM1	WRB	ENSP00000457386	ENSP00000327716	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane; Belongs to the WRB/GET1 family	0.418
WRB	SMIM1	ENSP00000327716	ENSP00000457386	Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane; Belongs to the WRB/GET1 family	Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family	0.418

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