| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABT1 | RNF151 | ENSP00000274849 | ENSP00000456566 | Activator of basal transcription 1; Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity); Belongs to the ESF2/ABP1 family | RING finger protein 151; May be involved in acrosome formation of spermatids; Ring finger proteins | 0.809 |
| CD40 | RNF151 | ENSP00000361359 | ENSP00000456566 | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion | RING finger protein 151; May be involved in acrosome formation of spermatids; Ring finger proteins | 0.561 |
| CT45A1 | FAM133A | ENSP00000470185 | ENSP00000318974 | Cancer/testis antigen family 45 member A1; Belongs to the CT45 family | Protein FAM133A; Family with sequence similarity 133 member A | 0.714 |
| CT45A1 | RNF151 | ENSP00000470185 | ENSP00000456566 | Cancer/testis antigen family 45 member A1; Belongs to the CT45 family | RING finger protein 151; May be involved in acrosome formation of spermatids; Ring finger proteins | 0.810 |
| FAM133A | CT45A1 | ENSP00000318974 | ENSP00000470185 | Protein FAM133A; Family with sequence similarity 133 member A | Cancer/testis antigen family 45 member A1; Belongs to the CT45 family | 0.714 |
| FAM133A | RNF151 | ENSP00000318974 | ENSP00000456566 | Protein FAM133A; Family with sequence similarity 133 member A | RING finger protein 151; May be involved in acrosome formation of spermatids; Ring finger proteins | 0.738 |
| NSMCE1 | RNF126 | ENSP00000355077 | ENSP00000292363 | Non-structural maintenance of chromosomes element 1 homolog; Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (AP [...] | E3 ubiquitin-protein ligase RNF126; E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates ’Lys-48’- and ’Lys-63’-linked polyubiquitination of substrates (By similarity). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their target [...] | 0.611 |
| NSMCE1 | RNF133 | ENSP00000355077 | ENSP00000344489 | Non-structural maintenance of chromosomes element 1 homolog; Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (AP [...] | E3 ubiquitin-protein ligase RNF133; Has E3 ubiquitin-protein ligase activity; Ring finger proteins | 0.485 |
| NSMCE1 | RNF151 | ENSP00000355077 | ENSP00000456566 | Non-structural maintenance of chromosomes element 1 homolog; Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (AP [...] | RING finger protein 151; May be involved in acrosome formation of spermatids; Ring finger proteins | 0.715 |
| NSMCE1 | UBE2D2 | ENSP00000355077 | ENSP00000381717 | Non-structural maintenance of chromosomes element 1 homolog; Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (AP [...] | Ubiquitin-conjugating enzyme E2 D2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of [...] | 0.508 |
| NSMCE1 | ZNRF4 | ENSP00000355077 | ENSP00000222033 | Non-structural maintenance of chromosomes element 1 homolog; Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (AP [...] | E3 ubiquitin-protein ligase ZNRF4; E3 ubiquitin-protein ligase which specifically induces ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum. Could have a role in spermatogenesis (By similarity); Ring finger proteins | 0.741 |
| RNF126 | NSMCE1 | ENSP00000292363 | ENSP00000355077 | E3 ubiquitin-protein ligase RNF126; E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates ’Lys-48’- and ’Lys-63’-linked polyubiquitination of substrates (By similarity). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their target [...] | Non-structural maintenance of chromosomes element 1 homolog; Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (AP [...] | 0.611 |
| RNF126 | RNF151 | ENSP00000292363 | ENSP00000456566 | E3 ubiquitin-protein ligase RNF126; E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates ’Lys-48’- and ’Lys-63’-linked polyubiquitination of substrates (By similarity). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their target [...] | RING finger protein 151; May be involved in acrosome formation of spermatids; Ring finger proteins | 0.655 |
| RNF126 | UBE2D2 | ENSP00000292363 | ENSP00000381717 | E3 ubiquitin-protein ligase RNF126; E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates ’Lys-48’- and ’Lys-63’-linked polyubiquitination of substrates (By similarity). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their target [...] | Ubiquitin-conjugating enzyme E2 D2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of [...] | 0.968 |
| RNF133 | NSMCE1 | ENSP00000344489 | ENSP00000355077 | E3 ubiquitin-protein ligase RNF133; Has E3 ubiquitin-protein ligase activity; Ring finger proteins | Non-structural maintenance of chromosomes element 1 homolog; Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (AP [...] | 0.485 |
| RNF133 | RNF151 | ENSP00000344489 | ENSP00000456566 | E3 ubiquitin-protein ligase RNF133; Has E3 ubiquitin-protein ligase activity; Ring finger proteins | RING finger protein 151; May be involved in acrosome formation of spermatids; Ring finger proteins | 0.630 |
| RNF151 | ABT1 | ENSP00000456566 | ENSP00000274849 | RING finger protein 151; May be involved in acrosome formation of spermatids; Ring finger proteins | Activator of basal transcription 1; Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity); Belongs to the ESF2/ABP1 family | 0.809 |
| RNF151 | CD40 | ENSP00000456566 | ENSP00000361359 | RING finger protein 151; May be involved in acrosome formation of spermatids; Ring finger proteins | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion | 0.561 |
| RNF151 | CT45A1 | ENSP00000456566 | ENSP00000470185 | RING finger protein 151; May be involved in acrosome formation of spermatids; Ring finger proteins | Cancer/testis antigen family 45 member A1; Belongs to the CT45 family | 0.810 |
| RNF151 | FAM133A | ENSP00000456566 | ENSP00000318974 | RING finger protein 151; May be involved in acrosome formation of spermatids; Ring finger proteins | Protein FAM133A; Family with sequence similarity 133 member A | 0.738 |
