| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASCL1 | GAD2 | ENSP00000266744 | ENSP00000365437 | Achaete-scute homolog 1; Transcription factor that plays a key role in neuronal differentiation- acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5’-CANNTG-3’) on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in mos [...] | Glutamate decarboxylase 2; Catalyzes the production of GABA | 0.455 |
| ASCL1 | SCRT1 | ENSP00000266744 | ENSP00000455711 | Achaete-scute homolog 1; Transcription factor that plays a key role in neuronal differentiation- acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5’-CANNTG-3’) on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in mos [...] | Transcriptional repressor scratch 1; Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation; SNAG transcriptional repressors | 0.711 |
| CDK5R2 | CELF3 | ENSP00000304250 | ENSP00000290583 | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | CUGBP Elav-like family member 3; RNA-binding protein involved in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA | 0.585 |
| CDK5R2 | KCNC1 | ENSP00000304250 | ENSP00000265969 | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | Potassium voltage-gated channel subfamily C member 1; Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action [...] | 0.472 |
| CDK5R2 | SCRT1 | ENSP00000304250 | ENSP00000455711 | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | Transcriptional repressor scratch 1; Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation; SNAG transcriptional repressors | 0.597 |
| CDK5R2 | SLC32A1 | ENSP00000304250 | ENSP00000217420 | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles; Solute carriers | 0.500 |
| CDK5R2 | SLC8A2 | ENSP00000304250 | ENSP00000236877 | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | Sodium/calcium exchanger 2; Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion; Belongs to the Ca(2+)-cation antiporter (CaCA) (TC [...] | 0.448 |
| CELF3 | CDK5R2 | ENSP00000290583 | ENSP00000304250 | CUGBP Elav-like family member 3; RNA-binding protein involved in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | 0.585 |
| CELF3 | KCNC1 | ENSP00000290583 | ENSP00000265969 | CUGBP Elav-like family member 3; RNA-binding protein involved in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA | Potassium voltage-gated channel subfamily C member 1; Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action [...] | 0.522 |
| CELF3 | SCRT1 | ENSP00000290583 | ENSP00000455711 | CUGBP Elav-like family member 3; RNA-binding protein involved in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA | Transcriptional repressor scratch 1; Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation; SNAG transcriptional repressors | 0.621 |
| CELF3 | SLC32A1 | ENSP00000290583 | ENSP00000217420 | CUGBP Elav-like family member 3; RNA-binding protein involved in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA | Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles; Solute carriers | 0.442 |
| CELF3 | SLC8A2 | ENSP00000290583 | ENSP00000236877 | CUGBP Elav-like family member 3; RNA-binding protein involved in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA | Sodium/calcium exchanger 2; Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion; Belongs to the Ca(2+)-cation antiporter (CaCA) (TC [...] | 0.459 |
| GAD2 | ASCL1 | ENSP00000365437 | ENSP00000266744 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Achaete-scute homolog 1; Transcription factor that plays a key role in neuronal differentiation- acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5’-CANNTG-3’) on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in mos [...] | 0.455 |
| GAD2 | KCNC1 | ENSP00000365437 | ENSP00000265969 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Potassium voltage-gated channel subfamily C member 1; Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action [...] | 0.563 |
| GAD2 | SCRT1 | ENSP00000365437 | ENSP00000455711 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Transcriptional repressor scratch 1; Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation; SNAG transcriptional repressors | 0.609 |
| GAD2 | SLC32A1 | ENSP00000365437 | ENSP00000217420 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles; Solute carriers | 0.994 |
| GAD2 | SLC6A1 | ENSP00000365437 | ENSP00000287766 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Sodium- and chloride-dependent GABA transporter 1; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily | 0.825 |
| KCNC1 | CDK5R2 | ENSP00000265969 | ENSP00000304250 | Potassium voltage-gated channel subfamily C member 1; Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action [...] | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | 0.472 |
| KCNC1 | CELF3 | ENSP00000265969 | ENSP00000290583 | Potassium voltage-gated channel subfamily C member 1; Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action [...] | CUGBP Elav-like family member 3; RNA-binding protein involved in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA | 0.522 |
| KCNC1 | GAD2 | ENSP00000265969 | ENSP00000365437 | Potassium voltage-gated channel subfamily C member 1; Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action [...] | Glutamate decarboxylase 2; Catalyzes the production of GABA | 0.563 |
