ZNF853 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ZNF853

Zinc finger protein 853; Zinc fingers C2H2-type (659 aa)

Predicted Functional Partners:

ZNF862

0.491

PTPN12

0.433

MTUS2

0.417

C10orf76

0.406

KCNN2

0.405

ICA1L

0.400

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C10orf76	ICA1L	ENSP00000359050	ENSP00000478645	UPF0668 protein C10orf76; Chromosome 10 open reading frame 76	Islet cell autoantigen 1-like protein; Classical BAR domain containing	0.521
C10orf76	MTUS2	ENSP00000359050	ENSP00000483729	UPF0668 protein C10orf76; Chromosome 10 open reading frame 76	Microtubule-associated tumor suppressor candidate 2; Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip; In the C-terminal section; belongs to the MTUS1 family	0.526
C10orf76	ZNF853	ENSP00000359050	ENSP00000455585	UPF0668 protein C10orf76; Chromosome 10 open reading frame 76	Zinc finger protein 853; Zinc fingers C2H2-type	0.406
ICA1L	C10orf76	ENSP00000478645	ENSP00000359050	Islet cell autoantigen 1-like protein; Classical BAR domain containing	UPF0668 protein C10orf76; Chromosome 10 open reading frame 76	0.521
ICA1L	MTUS2	ENSP00000478645	ENSP00000483729	Islet cell autoantigen 1-like protein; Classical BAR domain containing	Microtubule-associated tumor suppressor candidate 2; Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip; In the C-terminal section; belongs to the MTUS1 family	0.531
ICA1L	ZNF853	ENSP00000478645	ENSP00000455585	Islet cell autoantigen 1-like protein; Classical BAR domain containing	Zinc finger protein 853; Zinc fingers C2H2-type	0.400
KCNN2	ZNF853	ENSP00000427120	ENSP00000455585	Small conductance calcium-activated potassium channel protein 2; Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin; Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily	Zinc finger protein 853; Zinc fingers C2H2-type	0.405
MTUS2	C10orf76	ENSP00000483729	ENSP00000359050	Microtubule-associated tumor suppressor candidate 2; Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip; In the C-terminal section; belongs to the MTUS1 family	UPF0668 protein C10orf76; Chromosome 10 open reading frame 76	0.526
MTUS2	ICA1L	ENSP00000483729	ENSP00000478645	Microtubule-associated tumor suppressor candidate 2; Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip; In the C-terminal section; belongs to the MTUS1 family	Islet cell autoantigen 1-like protein; Classical BAR domain containing	0.531
MTUS2	ZNF853	ENSP00000483729	ENSP00000455585	Microtubule-associated tumor suppressor candidate 2; Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip; In the C-terminal section; belongs to the MTUS1 family	Zinc finger protein 853; Zinc fingers C2H2-type	0.417
PTPN12	ZNF853	ENSP00000248594	ENSP00000455585	Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at ’Tyr-1112’, ’Tyr-1196’, and/or ’Tyr-1248’; Protein tyrosine phosphatases, non-receptor type	Zinc finger protein 853; Zinc fingers C2H2-type	0.433
ZNF853	C10orf76	ENSP00000455585	ENSP00000359050	Zinc finger protein 853; Zinc fingers C2H2-type	UPF0668 protein C10orf76; Chromosome 10 open reading frame 76	0.406
ZNF853	ICA1L	ENSP00000455585	ENSP00000478645	Zinc finger protein 853; Zinc fingers C2H2-type	Islet cell autoantigen 1-like protein; Classical BAR domain containing	0.400
ZNF853	KCNN2	ENSP00000455585	ENSP00000427120	Zinc finger protein 853; Zinc fingers C2H2-type	Small conductance calcium-activated potassium channel protein 2; Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin; Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily	0.405
ZNF853	MTUS2	ENSP00000455585	ENSP00000483729	Zinc finger protein 853; Zinc fingers C2H2-type	Microtubule-associated tumor suppressor candidate 2; Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip; In the C-terminal section; belongs to the MTUS1 family	0.417
ZNF853	PTPN12	ENSP00000455585	ENSP00000248594	Zinc finger protein 853; Zinc fingers C2H2-type	Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at ’Tyr-1112’, ’Tyr-1196’, and/or ’Tyr-1248’; Protein tyrosine phosphatases, non-receptor type	0.433
ZNF853	ZNF862	ENSP00000455585	ENSP00000223210	Zinc finger protein 853; Zinc fingers C2H2-type	Zinc finger protein 862; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.491
ZNF862	ZNF853	ENSP00000223210	ENSP00000455585	Zinc finger protein 862; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Zinc finger protein 853; Zinc fingers C2H2-type	0.491

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2020

Credits

Access

Info

About