node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C15orf41 | C1orf146 | ENSP00000455397 | ENSP00000359401 | Uncharacterized protein C15orf41; Chromosome 15 open reading frame 41 | Uncharacterized protein C1orf146; Chromosome 1 open reading frame 146 | 0.767 |
C15orf41 | CDAN1 | ENSP00000455397 | ENSP00000348564 | Uncharacterized protein C15orf41; Chromosome 15 open reading frame 41 | Codanin-1; May act as a negative regulator of ASF1 in chromatin assembly | 0.706 |
C15orf41 | CDCA7 | ENSP00000455397 | ENSP00000306968 | Uncharacterized protein C15orf41; Chromosome 15 open reading frame 41 | Cell division cycle-associated protein 7; Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator | 0.558 |
C15orf41 | CSNK1A1 | ENSP00000455397 | ENSP00000421689 | Uncharacterized protein C15orf41; Chromosome 15 open reading frame 41 | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at ’Ser-45’. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration | 0.637 |
C15orf41 | DPH6 | ENSP00000455397 | ENSP00000256538 | Uncharacterized protein C15orf41; Chromosome 15 open reading frame 41 | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity) | 0.699 |
C15orf41 | KIF23 | ENSP00000455397 | ENSP00000260363 | Uncharacterized protein C15orf41; Chromosome 15 open reading frame 41 | Kinesin-like protein KIF23; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family | 0.544 |
C15orf41 | MEIS2 | ENSP00000455397 | ENSP00000453793 | Uncharacterized protein C15orf41; Chromosome 15 open reading frame 41 | Homeobox protein Meis2; Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1-PBX1b-MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in [...] | 0.608 |
C15orf41 | SEC23B | ENSP00000455397 | ENSP00000338844 | Uncharacterized protein C15orf41; Chromosome 15 open reading frame 41 | Protein transport protein Sec23B; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex | 0.669 |
C15orf41 | TMCO5A | ENSP00000455397 | ENSP00000327234 | Uncharacterized protein C15orf41; Chromosome 15 open reading frame 41 | Transmembrane and coiled-coil domains 5A; Belongs to the TMCO5 family | 0.571 |
C15orf41 | ZNF503 | ENSP00000455397 | ENSP00000361602 | Uncharacterized protein C15orf41; Chromosome 15 open reading frame 41 | Zinc finger protein 503; May function as a transcriptional repressor; Zinc fingers C2H2-type | 0.523 |
C1orf146 | C15orf41 | ENSP00000359401 | ENSP00000455397 | Uncharacterized protein C1orf146; Chromosome 1 open reading frame 146 | Uncharacterized protein C15orf41; Chromosome 15 open reading frame 41 | 0.767 |
C1orf146 | CDCA7 | ENSP00000359401 | ENSP00000306968 | Uncharacterized protein C1orf146; Chromosome 1 open reading frame 146 | Cell division cycle-associated protein 7; Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator | 0.597 |
CDAN1 | C15orf41 | ENSP00000348564 | ENSP00000455397 | Codanin-1; May act as a negative regulator of ASF1 in chromatin assembly | Uncharacterized protein C15orf41; Chromosome 15 open reading frame 41 | 0.706 |
CDAN1 | KIF23 | ENSP00000348564 | ENSP00000260363 | Codanin-1; May act as a negative regulator of ASF1 in chromatin assembly | Kinesin-like protein KIF23; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family | 0.472 |
CDAN1 | SEC23B | ENSP00000348564 | ENSP00000338844 | Codanin-1; May act as a negative regulator of ASF1 in chromatin assembly | Protein transport protein Sec23B; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex | 0.802 |
CDCA7 | C15orf41 | ENSP00000306968 | ENSP00000455397 | Cell division cycle-associated protein 7; Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator | Uncharacterized protein C15orf41; Chromosome 15 open reading frame 41 | 0.558 |
CDCA7 | C1orf146 | ENSP00000306968 | ENSP00000359401 | Cell division cycle-associated protein 7; Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator | Uncharacterized protein C1orf146; Chromosome 1 open reading frame 146 | 0.597 |
CDCA7 | KIF23 | ENSP00000306968 | ENSP00000260363 | Cell division cycle-associated protein 7; Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator | Kinesin-like protein KIF23; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family | 0.574 |
CSNK1A1 | C15orf41 | ENSP00000421689 | ENSP00000455397 | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at ’Ser-45’. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration | Uncharacterized protein C15orf41; Chromosome 15 open reading frame 41 | 0.637 |
CSNK1A1 | DPH6 | ENSP00000421689 | ENSP00000256538 | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at ’Ser-45’. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity) | 0.628 |