• Version:
  • 11.0 [archived version]
STRINGSTRING
SAMD5 SAMD5 FRMD3 FRMD3 CIB1 CIB1 LRRIQ3 LRRIQ3 USP46 USP46 NTN4 NTN4 TMC7 TMC7 ARFIP1 ARFIP1 STK40 STK40 USP45 USP45 SNX24 SNX24
"TMC7" - Transmembrane channel-like protein 7 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMC7Transmembrane channel-like protein 7; Probable ion channel; Transmembrane channel likes (758 aa)    
Predicted Functional Partners:
LRRIQ3
Leucine rich repeats and IQ motif containing 3 (624 aa)
           
  0.770
SAMD5
Sterile alpha motif domain containing 5 (173 aa)
           
  0.709
FRMD3
FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer; FERM domain containing (597 aa)
           
  0.669
ARFIP1
Arfaptin-1; Putative target protein of ADP-ribosylation factor; Classical BAR domain containing (373 aa)
           
  0.560
SNX24
Sorting nexin-24; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family (169 aa)
           
  0.549
CIB1
Calcium and integrin binding 1; EF-hand domain containing (231 aa)
       
      0.540
STK40
Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53- mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family (440 aa)
           
  0.528
USP45
Ubiquitin specific peptidase 45 (814 aa)
           
  0.517
USP46
Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2; Ubiquitin specific peptidases (366 aa)
           
  0.504
NTN4
Netrin-4; May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants; Netrins (628 aa)
           
  0.495
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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