node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CEBPD | RNF112 | ENSP00000386165 | ENSP00000454919 | CCAAT/enhancer-binding protein delta; Transcription activator that recognizes two different DNA motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB; Belongs to the bZIP family. C/EBP subfamily | Ring finger protein 112 | 0.502 |
GOLGA2 | RNF112 | ENSP00000416097 | ENSP00000454919 | Golgin subfamily A member 2; Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly- phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing teth [...] | Ring finger protein 112 | 0.509 |
LLGL1 | RNF112 | ENSP00000321537 | ENSP00000454919 | Lethal(2) giant larvae protein homolog 1; Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane | Ring finger protein 112 | 0.552 |
MYCBP2 | RNF112 | ENSP00000444596 | ENSP00000454919 | E3 ubiquitin-protein ligase MYCBP2; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis; Belongs to the highwire family | Ring finger protein 112 | 0.493 |
PCDH8 | RNF112 | ENSP00000367177 | ENSP00000454919 | Protocadherin-8; Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity); Non-clustered protocadherins | Ring finger protein 112 | 0.555 |
PCDH8 | STX1A | ENSP00000367177 | ENSP00000222812 | Protocadherin-8; Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity); Non-clustered protocadherins | Syntaxin-1A; Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm; Syntaxins | 0.433 |
PCDH8 | STX2 | ENSP00000367177 | ENSP00000376178 | Protocadherin-8; Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity); Non-clustered protocadherins | Syntaxin-2; Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm; Syntaxins | 0.550 |
RHBDD3 | RNF112 | ENSP00000216085 | ENSP00000454919 | Rhomboid domain containing 3 | Ring finger protein 112 | 0.619 |
RNF112 | CEBPD | ENSP00000454919 | ENSP00000386165 | Ring finger protein 112 | CCAAT/enhancer-binding protein delta; Transcription activator that recognizes two different DNA motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB; Belongs to the bZIP family. C/EBP subfamily | 0.502 |
RNF112 | GOLGA2 | ENSP00000454919 | ENSP00000416097 | Ring finger protein 112 | Golgin subfamily A member 2; Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly- phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing teth [...] | 0.509 |
RNF112 | LLGL1 | ENSP00000454919 | ENSP00000321537 | Ring finger protein 112 | Lethal(2) giant larvae protein homolog 1; Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane | 0.552 |
RNF112 | MYCBP2 | ENSP00000454919 | ENSP00000444596 | Ring finger protein 112 | E3 ubiquitin-protein ligase MYCBP2; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis; Belongs to the highwire family | 0.493 |
RNF112 | PCDH8 | ENSP00000454919 | ENSP00000367177 | Ring finger protein 112 | Protocadherin-8; Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity); Non-clustered protocadherins | 0.555 |
RNF112 | RHBDD3 | ENSP00000454919 | ENSP00000216085 | Ring finger protein 112 | Rhomboid domain containing 3 | 0.619 |
RNF112 | SNAP91 | ENSP00000454919 | ENSP00000400459 | Ring finger protein 112 | Clathrin coat assembly protein AP180; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity) | 0.478 |
RNF112 | ST8SIA2 | ENSP00000454919 | ENSP00000268164 | Ring finger protein 112 | Alpha-2,8-sialyltransferase 8B; May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression; Belongs to the glycosyltransferase 29 family | 0.606 |
RNF112 | STX1A | ENSP00000454919 | ENSP00000222812 | Ring finger protein 112 | Syntaxin-1A; Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm; Syntaxins | 0.652 |
RNF112 | STX2 | ENSP00000454919 | ENSP00000376178 | Ring finger protein 112 | Syntaxin-2; Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm; Syntaxins | 0.686 |
SNAP91 | RNF112 | ENSP00000400459 | ENSP00000454919 | Clathrin coat assembly protein AP180; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity) | Ring finger protein 112 | 0.478 |
SNAP91 | STX1A | ENSP00000400459 | ENSP00000222812 | Clathrin coat assembly protein AP180; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity) | Syntaxin-1A; Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm; Syntaxins | 0.427 |