node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGEF2 | CORO2B | ENSP00000354837 | ENSP00000454783 | Rho guanine nucleotide exchange factor 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed-9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellula [...] | Coronin-2B; May play a role in the reorganization of neuronal actin structure; Belongs to the WD repeat coronin family | 0.665 |
ARHGEF2 | PALLD | ENSP00000354837 | ENSP00000425556 | Rho guanine nucleotide exchange factor 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed-9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellula [...] | Palladin; Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have [...] | 0.467 |
ARHGEF2 | VCL | ENSP00000354837 | ENSP00000211998 | Rho guanine nucleotide exchange factor 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed-9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellula [...] | Vinculin; Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family | 0.599 |
ARPC1A | CORO2B | ENSP00000262942 | ENSP00000454783 | Actin-related protein 2/3 complex subunit 1A; Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks; Belongs to the WD repeat ARPC1 family | Coronin-2B; May play a role in the reorganization of neuronal actin structure; Belongs to the WD repeat coronin family | 0.606 |
ARPC1A | PALLD | ENSP00000262942 | ENSP00000425556 | Actin-related protein 2/3 complex subunit 1A; Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks; Belongs to the WD repeat ARPC1 family | Palladin; Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have [...] | 0.440 |
ARPC1A | VCL | ENSP00000262942 | ENSP00000211998 | Actin-related protein 2/3 complex subunit 1A; Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks; Belongs to the WD repeat ARPC1 family | Vinculin; Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family | 0.686 |
CORO2B | ARHGEF2 | ENSP00000454783 | ENSP00000354837 | Coronin-2B; May play a role in the reorganization of neuronal actin structure; Belongs to the WD repeat coronin family | Rho guanine nucleotide exchange factor 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed-9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellula [...] | 0.665 |
CORO2B | ARPC1A | ENSP00000454783 | ENSP00000262942 | Coronin-2B; May play a role in the reorganization of neuronal actin structure; Belongs to the WD repeat coronin family | Actin-related protein 2/3 complex subunit 1A; Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks; Belongs to the WD repeat ARPC1 family | 0.606 |
CORO2B | ITGA11 | ENSP00000454783 | ENSP00000327290 | Coronin-2B; May play a role in the reorganization of neuronal actin structure; Belongs to the WD repeat coronin family | Integrin alpha-11; Integrin alpha-11/beta-1 is a receptor for collagen | 0.805 |
CORO2B | KIF23 | ENSP00000454783 | ENSP00000260363 | Coronin-2B; May play a role in the reorganization of neuronal actin structure; Belongs to the WD repeat coronin family | Kinesin-like protein KIF23; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family | 0.680 |
CORO2B | PALLD | ENSP00000454783 | ENSP00000425556 | Coronin-2B; May play a role in the reorganization of neuronal actin structure; Belongs to the WD repeat coronin family | Palladin; Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have [...] | 0.594 |
CORO2B | PCCB | ENSP00000454783 | ENSP00000419027 | Coronin-2B; May play a role in the reorganization of neuronal actin structure; Belongs to the WD repeat coronin family | propionyl-CoA carboxylase beta subunit | 0.601 |
CORO2B | PXYLP1 | ENSP00000454783 | ENSP00000286353 | Coronin-2B; May play a role in the reorganization of neuronal actin structure; Belongs to the WD repeat coronin family | 2-phosphoxylose phosphatase 1; Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1- 4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation duri [...] | 0.610 |
CORO2B | TLE3 | ENSP00000454783 | ENSP00000452871 | Coronin-2B; May play a role in the reorganization of neuronal actin structure; Belongs to the WD repeat coronin family | Transducin-like enhancer protein 3; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity); WD repeat domain containing | 0.800 |
CORO2B | VCL | ENSP00000454783 | ENSP00000211998 | Coronin-2B; May play a role in the reorganization of neuronal actin structure; Belongs to the WD repeat coronin family | Vinculin; Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family | 0.718 |
CORO2B | ZDHHC18 | ENSP00000454783 | ENSP00000363257 | Coronin-2B; May play a role in the reorganization of neuronal actin structure; Belongs to the WD repeat coronin family | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK; Zinc fingers DHHC-type | 0.584 |
ITGA11 | CORO2B | ENSP00000327290 | ENSP00000454783 | Integrin alpha-11; Integrin alpha-11/beta-1 is a receptor for collagen | Coronin-2B; May play a role in the reorganization of neuronal actin structure; Belongs to the WD repeat coronin family | 0.805 |
ITGA11 | KIF23 | ENSP00000327290 | ENSP00000260363 | Integrin alpha-11; Integrin alpha-11/beta-1 is a receptor for collagen | Kinesin-like protein KIF23; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family | 0.642 |
ITGA11 | TLE3 | ENSP00000327290 | ENSP00000452871 | Integrin alpha-11; Integrin alpha-11/beta-1 is a receptor for collagen | Transducin-like enhancer protein 3; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity); WD repeat domain containing | 0.760 |
KIF23 | CORO2B | ENSP00000260363 | ENSP00000454783 | Kinesin-like protein KIF23; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family | Coronin-2B; May play a role in the reorganization of neuronal actin structure; Belongs to the WD repeat coronin family | 0.680 |