ANKRD66 protein (human) - STRING database

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ANKRD66

Ankyrin repeat domain-containing protein 66; Ankyrin repeat domain containing (251 aa)

Predicted Functional Partners:

TDRD6

0.595

TRAPPC8

0.587

MEP1A

0.559

RNF138

0.559

MEP1B

0.545

RNF125

0.519

PLA2G7

0.447

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD66	MEP1A	ENSP00000454770	ENSP00000230588	Ankyrin repeat domain-containing protein 66; Ankyrin repeat domain containing	Meprin A subunit alpha; Belongs to the peptidase M12A family	0.559
ANKRD66	MEP1B	ENSP00000454770	ENSP00000269202	Ankyrin repeat domain-containing protein 66; Ankyrin repeat domain containing	Meprin A subunit beta; Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1’ position. Known substrates include- FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components; Astacins	0.545
ANKRD66	PLA2G7	ENSP00000454770	ENSP00000274793	Ankyrin repeat domain-containing protein 66; Ankyrin repeat domain containing	Platelet-activating factor acetylhydrolase; Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids; Phospholipases	0.447
ANKRD66	RNF125	ENSP00000454770	ENSP00000217740	Ankyrin repeat domain-containing protein 66; Ankyrin repeat domain containing	E3 ubiquitin-protein ligase RNF125; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at ’Lys-181’, leading to DDX58/RIG-I degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation; Ring finger proteins	0.519
ANKRD66	RNF138	ENSP00000454770	ENSP00000261593	Ankyrin repeat domain-containing protein 66; Ankyrin repeat domain containing	E3 ubiquitin-protein ligase RNF138; E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double- strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ)- acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku comple [...]	0.559
ANKRD66	TDRD6	ENSP00000454770	ENSP00000346065	Ankyrin repeat domain-containing protein 66; Ankyrin repeat domain containing	Tudor domain-containing protein 6; Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA expression; Tudor domain containing	0.595
ANKRD66	TRAPPC8	ENSP00000454770	ENSP00000283351	Ankyrin repeat domain-containing protein 66; Ankyrin repeat domain containing	Trafficking protein particle complex subunit 8; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage; Trafficking protein particle complex	0.587
MEP1A	ANKRD66	ENSP00000230588	ENSP00000454770	Meprin A subunit alpha; Belongs to the peptidase M12A family	Ankyrin repeat domain-containing protein 66; Ankyrin repeat domain containing	0.559
MEP1A	MEP1B	ENSP00000230588	ENSP00000269202	Meprin A subunit alpha; Belongs to the peptidase M12A family	Meprin A subunit beta; Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1’ position. Known substrates include- FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components; Astacins	0.900
MEP1A	PLA2G7	ENSP00000230588	ENSP00000274793	Meprin A subunit alpha; Belongs to the peptidase M12A family	Platelet-activating factor acetylhydrolase; Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids; Phospholipases	0.573
MEP1A	RNF125	ENSP00000230588	ENSP00000217740	Meprin A subunit alpha; Belongs to the peptidase M12A family	E3 ubiquitin-protein ligase RNF125; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at ’Lys-181’, leading to DDX58/RIG-I degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation; Ring finger proteins	0.653
MEP1A	RNF138	ENSP00000230588	ENSP00000261593	Meprin A subunit alpha; Belongs to the peptidase M12A family	E3 ubiquitin-protein ligase RNF138; E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double- strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ)- acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku comple [...]	0.668
MEP1A	TDRD6	ENSP00000230588	ENSP00000346065	Meprin A subunit alpha; Belongs to the peptidase M12A family	Tudor domain-containing protein 6; Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA expression; Tudor domain containing	0.521
MEP1A	TRAPPC8	ENSP00000230588	ENSP00000283351	Meprin A subunit alpha; Belongs to the peptidase M12A family	Trafficking protein particle complex subunit 8; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage; Trafficking protein particle complex	0.667
MEP1B	ANKRD66	ENSP00000269202	ENSP00000454770	Meprin A subunit beta; Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1’ position. Known substrates include- FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components; Astacins	Ankyrin repeat domain-containing protein 66; Ankyrin repeat domain containing	0.545
MEP1B	MEP1A	ENSP00000269202	ENSP00000230588	Meprin A subunit beta; Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1’ position. Known substrates include- FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components; Astacins	Meprin A subunit alpha; Belongs to the peptidase M12A family	0.900
MEP1B	TRAPPC8	ENSP00000269202	ENSP00000283351	Meprin A subunit beta; Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1’ position. Known substrates include- FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components; Astacins	Trafficking protein particle complex subunit 8; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage; Trafficking protein particle complex	0.520
PLA2G7	ANKRD66	ENSP00000274793	ENSP00000454770	Platelet-activating factor acetylhydrolase; Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids; Phospholipases	Ankyrin repeat domain-containing protein 66; Ankyrin repeat domain containing	0.447
PLA2G7	MEP1A	ENSP00000274793	ENSP00000230588	Platelet-activating factor acetylhydrolase; Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids; Phospholipases	Meprin A subunit alpha; Belongs to the peptidase M12A family	0.573
PLA2G7	RNF125	ENSP00000274793	ENSP00000217740	Platelet-activating factor acetylhydrolase; Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids; Phospholipases	E3 ubiquitin-protein ligase RNF125; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at ’Lys-181’, leading to DDX58/RIG-I degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation; Ring finger proteins	0.518

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