GOLGA6L2 protein (human) - STRING database

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GOLGA6L2

Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family (909 aa)

Predicted Functional Partners:

C3orf30

0.657

FBXO39

0.644

APP

0.567

SPAG8

0.543

KIAA0100

0.531

PRSS55

0.511

FAM186A

0.510

CCDC33

0.451

LYPD6B

0.444

ERC1

0.437

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	GOLGA6L2	ENSP00000284981	ENSP00000454407	Amyloid-beta A4 protein; N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6); Endogenous ligands	Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family	0.567
C3orf30	GOLGA6L2	ENSP00000295622	ENSP00000454407	Uncharacterized protein C3orf30; Chromosome 3 open reading frame 30	Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family	0.657
CCDC33	GOLGA6L2	ENSP00000381795	ENSP00000454407	Coiled-coil domain containing 33	Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family	0.451
ERC1	GOLGA6L2	ENSP00000468263	ENSP00000454407	ELKS/Rab6-interacting/CAST family member 1; Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport	Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family	0.437
FAM186A	GOLGA6L2	ENSP00000329995	ENSP00000454407	Protein FAM186A; Family with sequence similarity 186 member A; Belongs to the FAM186 family	Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family	0.510
FBXO39	GOLGA6L2	ENSP00000321386	ENSP00000454407	F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other	Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family	0.644
FBXO39	PRSS55	ENSP00000321386	ENSP00000333003	F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other	Serine protease 55; Probable serine protease	0.743
FBXO39	SPAG8	ENSP00000321386	ENSP00000340982	F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9 [...]	0.818
GOLGA6L2	APP	ENSP00000454407	ENSP00000284981	Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family	Amyloid-beta A4 protein; N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6); Endogenous ligands	0.567
GOLGA6L2	C3orf30	ENSP00000454407	ENSP00000295622	Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family	Uncharacterized protein C3orf30; Chromosome 3 open reading frame 30	0.657
GOLGA6L2	CCDC33	ENSP00000454407	ENSP00000381795	Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family	Coiled-coil domain containing 33	0.451
GOLGA6L2	ERC1	ENSP00000454407	ENSP00000468263	Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family	ELKS/Rab6-interacting/CAST family member 1; Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport	0.437
GOLGA6L2	FAM186A	ENSP00000454407	ENSP00000329995	Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family	Protein FAM186A; Family with sequence similarity 186 member A; Belongs to the FAM186 family	0.510
GOLGA6L2	FBXO39	ENSP00000454407	ENSP00000321386	Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family	F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other	0.644
GOLGA6L2	KIAA0100	ENSP00000454407	ENSP00000436773	Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family	Protein KIAA0100; May be involved in membrane trafficking; Belongs to the SABRE family	0.531
GOLGA6L2	LYPD6B	ENSP00000454407	ENSP00000387077	Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family	Ly6/PLAUR domain-containing protein 6B; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifally alpha-3(3)-beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2)-alpha- 5-beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn- 398 but not its wild-type sequence; LY6/PLAUR domain containing	0.444
GOLGA6L2	PRSS55	ENSP00000454407	ENSP00000333003	Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family	Serine protease 55; Probable serine protease	0.511
GOLGA6L2	SPAG8	ENSP00000454407	ENSP00000340982	Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9 [...]	0.543
KIAA0100	GOLGA6L2	ENSP00000436773	ENSP00000454407	Protein KIAA0100; May be involved in membrane trafficking; Belongs to the SABRE family	Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family	0.531
LYPD6B	GOLGA6L2	ENSP00000387077	ENSP00000454407	Ly6/PLAUR domain-containing protein 6B; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifally alpha-3(3)-beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2)-alpha- 5-beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn- 398 but not its wild-type sequence; LY6/PLAUR domain containing	Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family	0.444

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