• Version:
  • 11.0 [archived version]
STRINGSTRING
MTRNR2L8 MTRNR2L8 TMEM203 TMEM203 NOL6 NOL6 TMEM185B TMEM185B AMZ2 AMZ2 EPB41L5 EPB41L5 GPR176 GPR176 RALB RALB ITFG1 ITFG1 PTPN4 PTPN4 FSIP1 FSIP1
"TMEM185B" - Transmembrane protein 185B in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM185BTransmembrane protein 185B (350 aa)    
Predicted Functional Partners:
EPB41L5
Band 4.1-like protein 5; May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells; FERM domain containing (733 aa)
           
  0.652
PTPN4
Tyrosine-protein phosphatase non-receptor type 4; May act at junctions between the membrane and the cytoskeleton; Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily (926 aa)
           
  0.649
RALB
Ras-related protein Ral-B; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis. In l [...] (206 aa)
     
   
  0.634
TMEM203
Transmembrane protein 203; Involved in the regulation of cellular calcium homeotasis. Required for spermatogenesis (136 aa)
     
   
  0.571
AMZ2
Archaemetzincin-2; Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze either neurogranin or angiotensin-2; Belongs to the peptidase M54 family (360 aa)
     
   
  0.523
MTRNR2L8
MT-RNR2 like 8; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family (24 aa)
           
  0.497
GPR176
G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production (515 aa)
           
  0.481
ITFG1
T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity); Belongs to the TIP family (612 aa)
           
  0.472
FSIP1
Fibrous sheath interacting protein 1; Belongs to the FSIP1 family (581 aa)
           
  0.459
NOL6
Nucleolar protein 6; Belongs to the NRAP family (1146 aa)
     
   
  0.446
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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