| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DHDH | ENSG00000258728 | ENSP00000221403 | ENSP00000451792 | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family | Uncharacterized protein | 0.515 |
| DHDH | GALE | ENSP00000221403 | ENSP00000483375 | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions- the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconver [...] | 0.611 |
| DHDH | GALK2 | ENSP00000221403 | ENSP00000453129 | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family | N-acetylgalactosamine kinase; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates; Belongs to the GHMP kinase family. GalK subfamily | 0.750 |
| DHDH | GALM | ENSP00000221403 | ENSP00000272252 | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) | 0.510 |
| DHDH | GALT | ENSP00000221403 | ENSP00000368119 | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family | Galactose-1-phosphate uridylyltransferase; Plays an important role in galactose metabolism | 0.524 |
| ENSG00000258728 | DHDH | ENSP00000451792 | ENSP00000221403 | Uncharacterized protein | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family | 0.515 |
| ENSG00000258728 | GALE | ENSP00000451792 | ENSP00000483375 | Uncharacterized protein | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions- the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconver [...] | 0.913 |
| ENSG00000258728 | GALK2 | ENSP00000451792 | ENSP00000453129 | Uncharacterized protein | N-acetylgalactosamine kinase; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates; Belongs to the GHMP kinase family. GalK subfamily | 0.852 |
| ENSG00000258728 | GALM | ENSP00000451792 | ENSP00000272252 | Uncharacterized protein | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) | 0.632 |
| ENSG00000258728 | PGM1 | ENSP00000451792 | ENSP00000360124 | Uncharacterized protein | Phosphoglucomutase-1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family | 0.445 |
| FRRS1 | GALK2 | ENSP00000287474 | ENSP00000453129 | Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm; Belongs to the FRRS1 family | N-acetylgalactosamine kinase; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates; Belongs to the GHMP kinase family. GalK subfamily | 0.705 |
| GALE | DHDH | ENSP00000483375 | ENSP00000221403 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions- the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconver [...] | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family | 0.611 |
| GALE | ENSG00000258728 | ENSP00000483375 | ENSP00000451792 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions- the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconver [...] | Uncharacterized protein | 0.913 |
| GALE | GALK2 | ENSP00000483375 | ENSP00000453129 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions- the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconver [...] | N-acetylgalactosamine kinase; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates; Belongs to the GHMP kinase family. GalK subfamily | 0.985 |
| GALE | GALM | ENSP00000483375 | ENSP00000272252 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions- the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconver [...] | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) | 0.962 |
| GALE | GALT | ENSP00000483375 | ENSP00000368119 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions- the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconver [...] | Galactose-1-phosphate uridylyltransferase; Plays an important role in galactose metabolism | 0.999 |
| GALE | PGM1 | ENSP00000483375 | ENSP00000360124 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions- the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconver [...] | Phosphoglucomutase-1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family | 0.486 |
| GALK2 | DHDH | ENSP00000453129 | ENSP00000221403 | N-acetylgalactosamine kinase; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates; Belongs to the GHMP kinase family. GalK subfamily | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family | 0.750 |
| GALK2 | ENSG00000258728 | ENSP00000453129 | ENSP00000451792 | N-acetylgalactosamine kinase; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates; Belongs to the GHMP kinase family. GalK subfamily | Uncharacterized protein | 0.852 |
| GALK2 | FRRS1 | ENSP00000453129 | ENSP00000287474 | N-acetylgalactosamine kinase; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates; Belongs to the GHMP kinase family. GalK subfamily | Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm; Belongs to the FRRS1 family | 0.705 |
