• Version:
  • 11.0 [archived version]
STRINGSTRING
CDCP2 CDCP2 ZNF518A ZNF518A C1orf194 C1orf194 OR2W1 OR2W1 C15orf57 C15orf57 CBX3 CBX3 VWA3A VWA3A ZC2HC1C ZC2HC1C OR5T1 OR5T1 AP2S1 AP2S1 AAGAB AAGAB
"C15orf57" - Coiled-coil domain-containing protein 32 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
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[Homology]
Score
C15orf57Coiled-coil domain-containing protein 32; Chromosome 15 open reading frame 57 (194 aa)    
Predicted Functional Partners:
AAGAB
Alpha- and gamma-adaptin-binding protein p34; May be involved in endocytic recycling of growth factor receptors such as EGFR (315 aa)
       
      0.825
AP2S1
AP-2 complex subunit sigma; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold b [...] (142 aa)
       
      0.816
CBX3
Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at ’Lys-9’, leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 ’Lys-9’ trimethylation, mediates the [...] (183 aa)
           
  0.676
C1orf194
Uncharacterized protein C1orf194; Chromosome 1 open reading frame 194 (157 aa)
           
  0.595
CDCP2
CUB domain containing protein 2 (449 aa)
           
  0.581
ZC2HC1C
Zinc finger C2HC-type containing 1C; Belongs to the ZC2HC1 family (456 aa)
           
  0.575
OR5T1
Olfactory receptor 5T1; Odorant receptor; Olfactory receptors, family 5 (326 aa)
           
  0.548
ZNF518A
Zinc finger protein 518A; May be involved in transcriptional regulation; Zinc fingers C2H2-type (1483 aa)
           
  0.538
VWA3A
Von Willebrand factor A domain containing 3A (1184 aa)
           
  0.529
OR2W1
Olfactory receptor 2W1; Odorant receptor; Olfactory receptors, family 2 (320 aa)
           
  0.518
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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