| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CRTC3 | ELAVL2 | ENSP00000268184 | ENSP00000380479 | CREB-regulated transcription coactivator 3; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ’Ser-133’ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX acti [...] | ELAV-like protein 2; Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR; Belongs to the RRM elav family | 0.634 |
| CRTC3 | EML5 | ENSP00000268184 | ENSP00000451998 | CREB-regulated transcription coactivator 3; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ’Ser-133’ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX acti [...] | Echinoderm microtubule-associated protein-like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; WD repeat domain containing | 0.713 |
| CRTC3 | PDE4D | ENSP00000268184 | ENSP00000345502 | CREB-regulated transcription coactivator 3; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ’Ser-133’ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX acti [...] | cAMP-specific 3’,5’-cyclic phosphodiesterase 4D; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes; Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily | 0.641 |
| CRTC3 | RGS7 | ENSP00000268184 | ENSP00000355523 | CREB-regulated transcription coactivator 3; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ’Ser-133’ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX acti [...] | Regulator of G-protein signaling 7; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling | 0.659 |
| CRTC3 | SLC6A11 | ENSP00000268184 | ENSP00000254488 | CREB-regulated transcription coactivator 3; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ’Ser-133’ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX acti [...] | Sodium- and chloride-dependent GABA transporter 3; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily | 0.646 |
| CRTC3 | TOP3B | ENSP00000268184 | ENSP00000381773 | CREB-regulated transcription coactivator 3; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ’Ser-133’ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX acti [...] | DNA topoisomerase 3-beta-1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils [...] | 0.403 |
| CRTC3 | ZNF500 | ENSP00000268184 | ENSP00000219478 | CREB-regulated transcription coactivator 3; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ’Ser-133’ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX acti [...] | Zinc finger protein 500; May be involved in transcriptional regulation; SCAN domain containing | 0.627 |
| ELAVL2 | CRTC3 | ENSP00000380479 | ENSP00000268184 | ELAV-like protein 2; Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR; Belongs to the RRM elav family | CREB-regulated transcription coactivator 3; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ’Ser-133’ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX acti [...] | 0.634 |
| ELAVL2 | EML5 | ENSP00000380479 | ENSP00000451998 | ELAV-like protein 2; Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR; Belongs to the RRM elav family | Echinoderm microtubule-associated protein-like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; WD repeat domain containing | 0.660 |
| ELAVL2 | PDE4D | ENSP00000380479 | ENSP00000345502 | ELAV-like protein 2; Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR; Belongs to the RRM elav family | cAMP-specific 3’,5’-cyclic phosphodiesterase 4D; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes; Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily | 0.643 |
| ELAVL2 | RGS7 | ENSP00000380479 | ENSP00000355523 | ELAV-like protein 2; Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR; Belongs to the RRM elav family | Regulator of G-protein signaling 7; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling | 0.690 |
| ELAVL2 | SLC6A11 | ENSP00000380479 | ENSP00000254488 | ELAV-like protein 2; Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR; Belongs to the RRM elav family | Sodium- and chloride-dependent GABA transporter 3; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily | 0.675 |
| ELAVL2 | TOP3B | ENSP00000380479 | ENSP00000381773 | ELAV-like protein 2; Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR; Belongs to the RRM elav family | DNA topoisomerase 3-beta-1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils [...] | 0.648 |
| ELAVL2 | ZNF500 | ENSP00000380479 | ENSP00000219478 | ELAV-like protein 2; Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR; Belongs to the RRM elav family | Zinc finger protein 500; May be involved in transcriptional regulation; SCAN domain containing | 0.485 |
| EML5 | CRTC3 | ENSP00000451998 | ENSP00000268184 | Echinoderm microtubule-associated protein-like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; WD repeat domain containing | CREB-regulated transcription coactivator 3; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ’Ser-133’ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX acti [...] | 0.713 |
| EML5 | ELAVL2 | ENSP00000451998 | ENSP00000380479 | Echinoderm microtubule-associated protein-like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; WD repeat domain containing | ELAV-like protein 2; Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR; Belongs to the RRM elav family | 0.660 |
| EML5 | LRRC16B | ENSP00000451998 | ENSP00000340467 | Echinoderm microtubule-associated protein-like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; WD repeat domain containing | Capping protein, Arp2/3 and myosin-I linker protein 3; Leucine rich repeat containing 16B; Belongs to the CARMIL family | 0.676 |
| EML5 | PDE4D | ENSP00000451998 | ENSP00000345502 | Echinoderm microtubule-associated protein-like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; WD repeat domain containing | cAMP-specific 3’,5’-cyclic phosphodiesterase 4D; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes; Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily | 0.662 |
| EML5 | PTPN21 | ENSP00000451998 | ENSP00000452414 | Echinoderm microtubule-associated protein-like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; WD repeat domain containing | Protein tyrosine phosphatase, non-receptor type 21; FERM domain containing | 0.636 |
| EML5 | RGS7 | ENSP00000451998 | ENSP00000355523 | Echinoderm microtubule-associated protein-like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; WD repeat domain containing | Regulator of G-protein signaling 7; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling | 0.697 |
