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  • 11.0 [archived version]
STRINGSTRING
ALX3 ALX3 LMAN2 LMAN2 SULT4A1 SULT4A1 ARMC4 ARMC4 PROX2 PROX2 ANGPTL1 ANGPTL1 VRTN VRTN YLPM1 YLPM1 AREL1 AREL1 TMEM165 TMEM165 SYNDIG1L SYNDIG1L
"PROX2" - Prospero homeobox protein 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
PROX2Prospero homeobox protein 2; Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity); Belongs to the Prospero homeodomain family (592 aa)    
Predicted Functional Partners:
VRTN
Vertnin; Vertebrae development associated; Belongs to the vertnin family (702 aa)
           
  0.753
ARMC4
Armadillo repeat-containing protein 4; Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly; Armadillo repeat containing (1044 aa)
           
  0.677
LMAN2
Vesicular integral-membrane protein VIP36; Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity) (356 aa)
           
  0.650
SULT4A1
Sulfotransferase 4A1; Atypical sulfotransferase family member with very low affinity for 3’-phospho-5’-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS; Sulfotransferases, cytosolic (284 aa)
           
  0.642
AREL1
Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation (823 aa)
           
  0.622
SYNDIG1L
Synapse differentiation-inducing gene protein 1-like; Interferon induced transmembrane protein domain containing (238 aa)
           
  0.603
YLPM1
YLP motif-containing protein 1; Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation; Protein phosphatase 1 regulatory subunits (2146 aa)
           
  0.596
ALX3
Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes (343 aa)
     
   
  0.557
ANGPTL1
Angiopoietin-related protein 1; Fibrinogen C domain containing; Angiopoietin like (491 aa)
     
   
  0.550
TMEM165
Transmembrane protein 165; May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis. Therefore, it may play an indirect role in protein glycosylation (324 aa)
           
  0.545
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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