DIO2 protein (human) - STRING database

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DIO2

Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins (309 aa)

Predicted Functional Partners:

DIO3

0.920

UGT2B11

0.905

UGT2B10

0.905

SULT1A2

0.902

SULT1A1

0.902

TG

0.817

TTR

0.813

UCP1

0.808

SECISBP2

0.804

CIDEA

0.772

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CIDEA	DIO2	ENSP00000320209	ENSP00000450980	Cell death activator CIDE-A; Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid tran [...]	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins	0.772
CIDEA	UCP1	ENSP00000320209	ENSP00000262999	Cell death activator CIDE-A; Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid tran [...]	Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in [...]	0.925
DIO2	CIDEA	ENSP00000450980	ENSP00000320209	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins	Cell death activator CIDE-A; Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid tran [...]	0.772
DIO2	DIO3	ENSP00000450980	ENSP00000427336	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins	Thyroxine 5-deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into RT3 (3,3’,5’-triiodothyronine) and of T3 (3,5,3’-triiodothyronine) into T2 (3,3’-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development	0.920
DIO2	SECISBP2	ENSP00000450980	ENSP00000364965	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins	Selenocysteine insertion sequence-binding protein 2; Binds to the SECIS element in the 3’-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB	0.804
DIO2	SULT1A1	ENSP00000450980	ENSP00000378972	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins	Sulfotransferase 1A1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk; Sulfotransferases, cytosolic	0.902
DIO2	SULT1A2	ENSP00000450980	ENSP00000378992	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins	Sulfotransferase 1A2; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk; Sulfotransferases, cytosolic	0.902
DIO2	TG	ENSP00000450980	ENSP00000220616	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins	Thyroglobulin; Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3); Belongs to the type-B carboxylesterase/lipase family	0.817
DIO2	TTR	ENSP00000450980	ENSP00000237014	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins	Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain; Gla domain containing	0.813
DIO2	UCP1	ENSP00000450980	ENSP00000262999	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins	Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in [...]	0.808
DIO2	UGT2B10	ENSP00000450980	ENSP00000265403	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins	UDP-glucuronosyltransferase 2B10; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds; Belongs to the UDP-glycosyltransferase family	0.905
DIO2	UGT2B11	ENSP00000450980	ENSP00000387683	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins	UDP-glucuronosyltransferase 2B11; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds; Belongs to the UDP-glycosyltransferase family	0.905
DIO3	DIO2	ENSP00000427336	ENSP00000450980	Thyroxine 5-deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into RT3 (3,3’,5’-triiodothyronine) and of T3 (3,5,3’-triiodothyronine) into T2 (3,3’-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins	0.920
DIO3	TG	ENSP00000427336	ENSP00000220616	Thyroxine 5-deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into RT3 (3,3’,5’-triiodothyronine) and of T3 (3,5,3’-triiodothyronine) into T2 (3,3’-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development	Thyroglobulin; Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3); Belongs to the type-B carboxylesterase/lipase family	0.434
SECISBP2	DIO2	ENSP00000364965	ENSP00000450980	Selenocysteine insertion sequence-binding protein 2; Binds to the SECIS element in the 3’-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins	0.804
SULT1A1	DIO2	ENSP00000378972	ENSP00000450980	Sulfotransferase 1A1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk; Sulfotransferases, cytosolic	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins	0.902
SULT1A1	SULT1A2	ENSP00000378972	ENSP00000378992	Sulfotransferase 1A1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk; Sulfotransferases, cytosolic	Sulfotransferase 1A2; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk; Sulfotransferases, cytosolic	0.995
SULT1A2	DIO2	ENSP00000378992	ENSP00000450980	Sulfotransferase 1A2; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk; Sulfotransferases, cytosolic	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins	0.902
SULT1A2	SULT1A1	ENSP00000378992	ENSP00000378972	Sulfotransferase 1A2; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk; Sulfotransferases, cytosolic	Sulfotransferase 1A1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk; Sulfotransferases, cytosolic	0.995
TG	DIO2	ENSP00000220616	ENSP00000450980	Thyroglobulin; Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3); Belongs to the type-B carboxylesterase/lipase family	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins	0.817

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