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  • 11.0 [archived version]
STRINGSTRING
LRRC39 LRRC39 LRRIQ3 LRRIQ3 TNNI3K TNNI3K ENSG00000124208 ENSG00000124208 SORBS2 SORBS2 ENSG00000259030 ENSG00000259030 INS-IGF2 INS-IGF2 ENSG00000259040 ENSG00000259040 HHLA1 HHLA1 ENSG00000259399 ENSG00000259399 ZC3H10 ZC3H10
"ENSG00000259030" - FPGT-TNNI3K readthrough in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSG00000259030FPGT-TNNI3K readthrough; Ankyrin repeat domain containing (949 aa)    
Predicted Functional Partners:
LRRIQ3
Leucine rich repeats and IQ motif containing 3 (624 aa)
       
 
  0.819
TNNI3K
Serine/threonine-protein kinase TNNI3K; May play a role in cardiac physiology; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily (835 aa)
     
 
0.806
ENSG00000259040
BLOC1S5-TXNDC5 readthrough (360 aa)
       
 
  0.557
ENSG00000259399
TGIF2-C20orf24 readthrough (155 aa)
           
  0.535
SORBS2
Sorbin and SH3 domain-containing protein 2; Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Isoform 6 increases water and sodium absorption in the intestine and g [...] (1200 aa)
       
 
  0.533
ZC3H10
Zinc finger CCCH domain-containing protein 10; Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5’-GCAGCGC-3’ on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA; Zinc fingers CCCH-type (434 aa)
           
  0.473
ENSG00000124208
TMEM189-UBE2V1 readthrough; Belongs to the ubiquitin-conjugating enzyme family (370 aa)
           
  0.472
INS-IGF2
Insulin, isoform 2; INS-IGF2 readthrough (200 aa)
       
 
  0.453
LRRC39
Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart (339 aa)
       
 
  0.453
HHLA1
HERV-H LTR-associating 1 (543 aa)
           
  0.450
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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