| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANAPC7 | CEP95 | ENSP00000394394 | ENSP00000450461 | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains; Belongs to the APC7 family | Centrosomal protein 95 | 0.531 |
| ANAPC7 | FAM184A | ENSP00000394394 | ENSP00000342604 | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains; Belongs to the APC7 family | Protein FAM184A; Family with sequence similarity 184 member A | 0.526 |
| ANAPC7 | LRRC8D | ENSP00000394394 | ENSP00000338887 | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains; Belongs to the APC7 family | Volume-regulated anion channel subunit LRRC8D; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. LRRC8A and LRRC8D are required for the uptak [...] | 0.425 |
| C17orf85 | CEP95 | ENSP00000373657 | ENSP00000450461 | Nuclear cap-binding protein subunit 3; Associates with NCBP1/CBP80 to form an alternative cap- binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress [...] | Centrosomal protein 95 | 0.594 |
| C17orf85 | TSC22D4 | ENSP00000373657 | ENSP00000300181 | Nuclear cap-binding protein subunit 3; Associates with NCBP1/CBP80 to form an alternative cap- binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress [...] | TSC22 domain family protein 4; Transcriptional repressor | 0.439 |
| CEP95 | ANAPC7 | ENSP00000450461 | ENSP00000394394 | Centrosomal protein 95 | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains; Belongs to the APC7 family | 0.531 |
| CEP95 | C17orf85 | ENSP00000450461 | ENSP00000373657 | Centrosomal protein 95 | Nuclear cap-binding protein subunit 3; Associates with NCBP1/CBP80 to form an alternative cap- binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress [...] | 0.594 |
| CEP95 | FAM184A | ENSP00000450461 | ENSP00000342604 | Centrosomal protein 95 | Protein FAM184A; Family with sequence similarity 184 member A | 0.566 |
| CEP95 | GLYR1 | ENSP00000450461 | ENSP00000322716 | Centrosomal protein 95 | Putative oxidoreductase GLYR1; Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity. Recognizes and binds trimethylated ’Lys-36’ of histone H3 (H3K36me3). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6; Belongs to the 3-hydroxyisobutyrate dehydrogenase family. NP60 subfamily | 0.540 |
| CEP95 | LRRC27 | ENSP00000450461 | ENSP00000357603 | Centrosomal protein 95 | Leucine-rich repeat-containing protein 27; Leucine rich repeat containing 27 | 0.496 |
| CEP95 | LRRC8D | ENSP00000450461 | ENSP00000338887 | Centrosomal protein 95 | Volume-regulated anion channel subunit LRRC8D; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. LRRC8A and LRRC8D are required for the uptak [...] | 0.468 |
| CEP95 | PRR23C | ENSP00000450461 | ENSP00000396648 | Centrosomal protein 95 | Proline-rich protein 23C; Proline rich 23C; Belongs to the PRR23 family | 0.543 |
| CEP95 | RSPRY1 | ENSP00000450461 | ENSP00000443176 | Centrosomal protein 95 | Ring finger and SPRY domain containing 1 | 0.510 |
| CEP95 | SPICE1 | ENSP00000450461 | ENSP00000295872 | Centrosomal protein 95 | Spindle and centriole-associated protein 1; Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis | 0.476 |
| CEP95 | TSC22D4 | ENSP00000450461 | ENSP00000300181 | Centrosomal protein 95 | TSC22 domain family protein 4; Transcriptional repressor | 0.485 |
| FAM184A | ANAPC7 | ENSP00000342604 | ENSP00000394394 | Protein FAM184A; Family with sequence similarity 184 member A | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains; Belongs to the APC7 family | 0.526 |
| FAM184A | CEP95 | ENSP00000342604 | ENSP00000450461 | Protein FAM184A; Family with sequence similarity 184 member A | Centrosomal protein 95 | 0.566 |
| FAM184A | LRRC8D | ENSP00000342604 | ENSP00000338887 | Protein FAM184A; Family with sequence similarity 184 member A | Volume-regulated anion channel subunit LRRC8D; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. LRRC8A and LRRC8D are required for the uptak [...] | 0.497 |
| GLYR1 | CEP95 | ENSP00000322716 | ENSP00000450461 | Putative oxidoreductase GLYR1; Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity. Recognizes and binds trimethylated ’Lys-36’ of histone H3 (H3K36me3). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6; Belongs to the 3-hydroxyisobutyrate dehydrogenase family. NP60 subfamily | Centrosomal protein 95 | 0.540 |
| LRRC27 | CEP95 | ENSP00000357603 | ENSP00000450461 | Leucine-rich repeat-containing protein 27; Leucine rich repeat containing 27 | Centrosomal protein 95 | 0.496 |
