ENSG00000257411 protein (human)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

gene neighborhood

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textmining

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Score

ENSG00000257411

Uncharacterized protein (160 aa)

Predicted Functional Partners:

MRTO4

0.955

GTPBP4

0.952

NSA2

0.943

NIFK

0.941

RPF2

0.941

SDAD1

0.940

RSL24D1

0.940

PES1

0.937

GNL2

0.930

NLE1

0.926

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSG00000257411	GNL2	ENSP00000449770	ENSP00000362153	Uncharacterized protein	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation	0.930
ENSG00000257411	GTPBP4	ENSP00000449770	ENSP00000354040	Uncharacterized protein	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily	0.952
ENSG00000257411	MRTO4	ENSP00000449770	ENSP00000364320	Uncharacterized protein	mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes	0.955
ENSG00000257411	NIFK	ENSP00000449770	ENSP00000285814	Uncharacterized protein	Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing	0.941
ENSG00000257411	NLE1	ENSP00000449770	ENSP00000413572	Uncharacterized protein	Notchless protein homolog 1; Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity); Belongs to the NLE1/RSA4 family	0.926
ENSG00000257411	NSA2	ENSP00000449770	ENSP00000483484	Uncharacterized protein	Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity)	0.943
ENSG00000257411	PES1	ENSP00000449770	ENSP00000346725	Uncharacterized protein	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family	0.937
ENSG00000257411	RPF2	ENSP00000449770	ENSP00000402338	Uncharacterized protein	Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus	0.941
ENSG00000257411	RSL24D1	ENSP00000449770	ENSP00000260443	Uncharacterized protein	Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity); Belongs to the eukaryotic ribosomal protein eL24 family	0.940
ENSG00000257411	SDAD1	ENSP00000449770	ENSP00000348596	Uncharacterized protein	Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family	0.940
GNL2	ENSG00000257411	ENSP00000362153	ENSP00000449770	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation	Uncharacterized protein	0.930
GNL2	GTPBP4	ENSP00000362153	ENSP00000354040	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily	0.999
GNL2	MRTO4	ENSP00000362153	ENSP00000364320	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation	mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes	0.993
GNL2	NIFK	ENSP00000362153	ENSP00000285814	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation	Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing	0.989
GNL2	NLE1	ENSP00000362153	ENSP00000413572	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation	Notchless protein homolog 1; Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity); Belongs to the NLE1/RSA4 family	0.977
GNL2	NSA2	ENSP00000362153	ENSP00000483484	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation	Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity)	0.999
GNL2	PES1	ENSP00000362153	ENSP00000346725	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family	0.990
GNL2	RPF2	ENSP00000362153	ENSP00000402338	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation	Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus	0.996
GNL2	RSL24D1	ENSP00000362153	ENSP00000260443	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation	Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity); Belongs to the eukaryotic ribosomal protein eL24 family	0.991
GNL2	SDAD1	ENSP00000362153	ENSP00000348596	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation	Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family	0.967

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