| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BPTF | C17orf49 | ENSP00000307208 | ENSP00000448598 | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family | Chromatin complexes subunit BAP18; Component of chromatin complexes such as the MLL1/MLL and NURF complexes; Myb/SANT domain containing | 0.944 |
| BPTF | HMGXB4 | ENSP00000307208 | ENSP00000216106 | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family | HMG domain-containing protein 4; Negatively regulates Wnt/beta-catenin signaling during development; Non-canonical high mobility group | 0.996 |
| BPTF | KAT8 | ENSP00000307208 | ENSP00000406037 | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family | Histone acetyltransferase KAT8; Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at ’Lys-120’ | 0.405 |
| BPTF | RBBP4 | ENSP00000307208 | ENSP00000362592 | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome re [...] | 0.976 |
| BPTF | SMARCA1 | ENSP00000307208 | ENSP00000360162 | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family | Probable global transcription activator SNF2L1; Energy-transducing component of NURF (nucleosome- remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilitate the perturbation of chromatin structure in an ATP-dependent manner. Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression. May be involved in the development of luteal cells; Myb/SANT domain containing | 0.997 |
| BPTF | SMARCA5 | ENSP00000307208 | ENSP00000283131 | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. [...] | 0.997 |
| BPTF | WDR5 | ENSP00000307208 | ENSP00000351446 | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family | WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at ’Lys-4’. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation; Belongs to the WD repeat WDR5/wds family | 0.742 |
| C17orf49 | BPTF | ENSP00000448598 | ENSP00000307208 | Chromatin complexes subunit BAP18; Component of chromatin complexes such as the MLL1/MLL and NURF complexes; Myb/SANT domain containing | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family | 0.944 |
| C17orf49 | HMGXB4 | ENSP00000448598 | ENSP00000216106 | Chromatin complexes subunit BAP18; Component of chromatin complexes such as the MLL1/MLL and NURF complexes; Myb/SANT domain containing | HMG domain-containing protein 4; Negatively regulates Wnt/beta-catenin signaling during development; Non-canonical high mobility group | 0.944 |
| C17orf49 | KAT8 | ENSP00000448598 | ENSP00000406037 | Chromatin complexes subunit BAP18; Component of chromatin complexes such as the MLL1/MLL and NURF complexes; Myb/SANT domain containing | Histone acetyltransferase KAT8; Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at ’Lys-120’ | 0.918 |
| C17orf49 | PRPF31 | ENSP00000448598 | ENSP00000324122 | Chromatin complexes subunit BAP18; Component of chromatin complexes such as the MLL1/MLL and NURF complexes; Myb/SANT domain containing | U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | 0.903 |
| C17orf49 | RBBP4 | ENSP00000448598 | ENSP00000362592 | Chromatin complexes subunit BAP18; Component of chromatin complexes such as the MLL1/MLL and NURF complexes; Myb/SANT domain containing | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome re [...] | 0.925 |
| C17orf49 | RUVBL1 | ENSP00000448598 | ENSP00000318297 | Chromatin complexes subunit BAP18; Component of chromatin complexes such as the MLL1/MLL and NURF complexes; Myb/SANT domain containing | RuvB-like 1; May be able to bind plasminogen at cell surface and enhance plasminogen activation; AAA ATPases | 0.906 |
| C17orf49 | RUVBL2 | ENSP00000448598 | ENSP00000473172 | Chromatin complexes subunit BAP18; Component of chromatin complexes such as the MLL1/MLL and NURF complexes; Myb/SANT domain containing | RuvB-like 2; Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes; Belongs to the RuvB family | 0.902 |
| C17orf49 | SMARCA1 | ENSP00000448598 | ENSP00000360162 | Chromatin complexes subunit BAP18; Component of chromatin complexes such as the MLL1/MLL and NURF complexes; Myb/SANT domain containing | Probable global transcription activator SNF2L1; Energy-transducing component of NURF (nucleosome- remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilitate the perturbation of chromatin structure in an ATP-dependent manner. Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression. May be involved in the development of luteal cells; Myb/SANT domain containing | 0.919 |
| C17orf49 | SMARCA5 | ENSP00000448598 | ENSP00000283131 | Chromatin complexes subunit BAP18; Component of chromatin complexes such as the MLL1/MLL and NURF complexes; Myb/SANT domain containing | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. [...] | 0.920 |
| C17orf49 | WDR5 | ENSP00000448598 | ENSP00000351446 | Chromatin complexes subunit BAP18; Component of chromatin complexes such as the MLL1/MLL and NURF complexes; Myb/SANT domain containing | WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at ’Lys-4’. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation; Belongs to the WD repeat WDR5/wds family | 0.919 |
| HMGXB4 | BPTF | ENSP00000216106 | ENSP00000307208 | HMG domain-containing protein 4; Negatively regulates Wnt/beta-catenin signaling during development; Non-canonical high mobility group | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family | 0.996 |
| HMGXB4 | C17orf49 | ENSP00000216106 | ENSP00000448598 | HMG domain-containing protein 4; Negatively regulates Wnt/beta-catenin signaling during development; Non-canonical high mobility group | Chromatin complexes subunit BAP18; Component of chromatin complexes such as the MLL1/MLL and NURF complexes; Myb/SANT domain containing | 0.944 |
| HMGXB4 | RBBP4 | ENSP00000216106 | ENSP00000362592 | HMG domain-containing protein 4; Negatively regulates Wnt/beta-catenin signaling during development; Non-canonical high mobility group | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome re [...] | 0.979 |
