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STRINGSTRING
IRS4 IRS4 NECAB1 NECAB1 CFAP61 CFAP61 PDE9A PDE9A C12orf75 C12orf75 ITLN2 ITLN2 SFXN3 SFXN3 HDHD3 HDHD3 TEX264 TEX264
"C12orf75" - Overexpressed in colon carcinoma 1 protein in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
C12orf75Overexpressed in colon carcinoma 1 protein; Chromosome 12 open reading frame 75 (63 aa)    
Predicted Functional Partners:
IRS4
Insulin receptor substrate 4; Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kina [...] (1257 aa)
            
  0.535
PDE9A
High affinity cGMP-specific 3’,5’-cyclic phosphodiesterase 9A; Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific- compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide- dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ab [...] (593 aa)
        
      0.521
HDHD3
Haloacid dehalogenase like hydrolase domain containing 3 (251 aa)
            
  0.448
CFAP61
Cilia- and flagella-associated protein 61; May regulate cilium motility through its role in the assembly of the axonemal radial spokes; Cilia and flagella associated (1237 aa)
            
  0.441
NECAB1
N-terminal EF-hand calcium binding protein 1; EF-hand domain containing (351 aa)
            
  0.420
TEX264
Testis-expressed protein 264; Testis expressed 264 (313 aa)
            
  0.418
ITLN2
Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing (325 aa)
            
  0.400
SFXN3
Sideroflexin-3; Potential iron transporter; Sideroflexins (325 aa)
            
  0.400
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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