node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC5L | KRT4 | ENSP00000360532 | ENSP00000448220 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | Keratin, type II cytoskeletal 4; Keratins, type II; Belongs to the intermediate filament family | 0.980 |
KRT13 | KRT14 | ENSP00000246635 | ENSP00000167586 | Keratin, type I cytoskeletal 13; Keratins, type I | Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro | 0.915 |
KRT13 | KRT15 | ENSP00000246635 | ENSP00000254043 | Keratin, type I cytoskeletal 13; Keratins, type I | Keratin, type I cytoskeletal 15; Keratins, type I | 0.952 |
KRT13 | KRT16 | ENSP00000246635 | ENSP00000301653 | Keratin, type I cytoskeletal 13; Keratins, type I | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach- required for some inflammatory checkpoint for the skin barrier maintenance | 0.920 |
KRT13 | KRT17 | ENSP00000246635 | ENSP00000308452 | Keratin, type I cytoskeletal 13; Keratins, type I | Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a mark [...] | 0.914 |
KRT13 | KRT18 | ENSP00000246635 | ENSP00000373487 | Keratin, type I cytoskeletal 13; Keratins, type I | Keratin, type I cytoskeletal 18; Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection; Keratins, type I | 0.910 |
KRT13 | KRT19 | ENSP00000246635 | ENSP00000355124 | Keratin, type I cytoskeletal 13; Keratins, type I | Keratin, type I cytoskeletal 19; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle; Keratins, type I | 0.914 |
KRT13 | KRT28 | ENSP00000246635 | ENSP00000305263 | Keratin, type I cytoskeletal 13; Keratins, type I | Keratin, type I cytoskeletal 28; Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs) | 0.900 |
KRT13 | KRT4 | ENSP00000246635 | ENSP00000448220 | Keratin, type I cytoskeletal 13; Keratins, type I | Keratin, type II cytoskeletal 4; Keratins, type II; Belongs to the intermediate filament family | 0.961 |
KRT13 | KRT9 | ENSP00000246635 | ENSP00000246662 | Keratin, type I cytoskeletal 13; Keratins, type I | Keratin, type I cytoskeletal 9; May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly; Belongs to the intermediate filament family | 0.907 |
KRT14 | KRT13 | ENSP00000167586 | ENSP00000246635 | Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro | Keratin, type I cytoskeletal 13; Keratins, type I | 0.915 |
KRT14 | KRT15 | ENSP00000167586 | ENSP00000254043 | Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro | Keratin, type I cytoskeletal 15; Keratins, type I | 0.934 |
KRT14 | KRT16 | ENSP00000167586 | ENSP00000301653 | Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach- required for some inflammatory checkpoint for the skin barrier maintenance | 0.967 |
KRT14 | KRT17 | ENSP00000167586 | ENSP00000308452 | Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro | Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a mark [...] | 0.963 |
KRT14 | KRT18 | ENSP00000167586 | ENSP00000373487 | Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro | Keratin, type I cytoskeletal 18; Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection; Keratins, type I | 0.906 |
KRT14 | KRT19 | ENSP00000167586 | ENSP00000355124 | Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro | Keratin, type I cytoskeletal 19; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle; Keratins, type I | 0.908 |
KRT14 | KRT28 | ENSP00000167586 | ENSP00000305263 | Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro | Keratin, type I cytoskeletal 28; Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs) | 0.903 |
KRT14 | KRT4 | ENSP00000167586 | ENSP00000448220 | Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro | Keratin, type II cytoskeletal 4; Keratins, type II; Belongs to the intermediate filament family | 0.945 |
KRT14 | KRT9 | ENSP00000167586 | ENSP00000246662 | Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro | Keratin, type I cytoskeletal 9; May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly; Belongs to the intermediate filament family | 0.919 |
KRT15 | KRT13 | ENSP00000254043 | ENSP00000246635 | Keratin, type I cytoskeletal 15; Keratins, type I | Keratin, type I cytoskeletal 13; Keratins, type I | 0.952 |