| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CGI-74 | CRNKL1 | ENSP00000347005 | ENSP00000366557 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | 0.695 |
| CGI-74 | DDX46 | ENSP00000347005 | ENSP00000416534 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Probable ATP-dependent RNA helicase DDX46; Plays an essential role in splicing, either prior to, or during splicing A complex formation; Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily | 0.442 |
| CGI-74 | LUC7L2 | ENSP00000347005 | ENSP00000440222 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | 0.540 |
| CGI-74 | PRPF40B | ENSP00000347005 | ENSP00000448073 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing | 0.939 |
| CGI-74 | RBM25 | ENSP00000347005 | ENSP00000261973 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5’-splice site (5’-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5’-ss usage through the 5’-CGGGCA-3’ RNA sequence. Its association with LUC7 [...] | 0.873 |
| CGI-74 | SF3A1 | ENSP00000347005 | ENSP00000215793 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Splicing factor 3A subunit 1; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex; U2 small nucleolar ribonucleoprotein | 0.724 |
| CGI-74 | SF3B1 | ENSP00000347005 | ENSP00000335321 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | 0.843 |
| CGI-74 | SNRNP70 | ENSP00000347005 | ENSP00000472998 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5’ splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA; RNA binding motif containing | 0.970 |
| CGI-74 | U2AF2 | ENSP00000347005 | ENSP00000307863 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Splicing factor U2AF 65 kDa subunit; Necessary for the splicing of pre-mRNA. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the [...] | 0.861 |
| CRNKL1 | CGI-74 | ENSP00000366557 | ENSP00000347005 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | 0.695 |
| CRNKL1 | DDX46 | ENSP00000366557 | ENSP00000416534 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | Probable ATP-dependent RNA helicase DDX46; Plays an essential role in splicing, either prior to, or during splicing A complex formation; Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily | 0.939 |
| CRNKL1 | LUC7L2 | ENSP00000366557 | ENSP00000440222 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | 0.679 |
| CRNKL1 | PRPF40B | ENSP00000366557 | ENSP00000448073 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing | 0.950 |
| CRNKL1 | RBM25 | ENSP00000366557 | ENSP00000261973 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5’-splice site (5’-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5’-ss usage through the 5’-CGGGCA-3’ RNA sequence. Its association with LUC7 [...] | 0.580 |
| CRNKL1 | SF3A1 | ENSP00000366557 | ENSP00000215793 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | Splicing factor 3A subunit 1; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex; U2 small nucleolar ribonucleoprotein | 0.950 |
| CRNKL1 | SF3B1 | ENSP00000366557 | ENSP00000335321 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | 0.993 |
| CRNKL1 | SNRNP70 | ENSP00000366557 | ENSP00000472998 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5’ splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA; RNA binding motif containing | 0.947 |
| CRNKL1 | U2AF2 | ENSP00000366557 | ENSP00000307863 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | Splicing factor U2AF 65 kDa subunit; Necessary for the splicing of pre-mRNA. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the [...] | 0.989 |
| DDX46 | CGI-74 | ENSP00000416534 | ENSP00000347005 | Probable ATP-dependent RNA helicase DDX46; Plays an essential role in splicing, either prior to, or during splicing A complex formation; Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | 0.442 |
| DDX46 | CRNKL1 | ENSP00000416534 | ENSP00000366557 | Probable ATP-dependent RNA helicase DDX46; Plays an essential role in splicing, either prior to, or during splicing A complex formation; Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | 0.939 |
