• Version:
  • 11.0 [archived version]
STRINGSTRING
TXNL1 TXNL1 SOX6 SOX6 UBB UBB GIF GIF DDX4 DDX4 DAZAP2 DAZAP2 DAZAP1 DAZAP1 DAZL DAZL BOLL BOLL SLAIN1 SLAIN1 TOB2 TOB2
"DAZAP2" - DAZ associated protein 2 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
DAZAP2DAZ associated protein 2 (207 aa)    
Predicted Functional Partners:
DAZL
Deleted in azoospermia-like; RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3’-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity); Belongs to the RRM DAZ family (315 aa)
       
 
  0.939
DAZAP1
DAZ-associated protein 1; RNA-binding protein, which may be required during spermatogenesis (407 aa)
           
  0.930
BOLL
Protein boule-like; Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation (By similarity); Belongs to the RRM DAZ family (295 aa)
           
  0.800
SLAIN1
SLAIN motif-containing protein 1; Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation; Belongs to the SLAIN motif-containing family (590 aa)
           
  0.743
TXNL1
Thioredoxin-like protein 1; Active thioredoxin with a redox potential of about -250 mV (289 aa)
           
  0.649
TOB2
Protein Tob2; Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases; Belongs to the BTG family (344 aa)
           
  0.641
GIF
Gastric intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis (417 aa)
           
  0.609
SOX6
Transcription factor SOX-6; Transcriptional activator. Binds specifically to the DNA sequence 5’-AACAAT-3’. Plays a key role in several developmental processes, including neurogenesis and skeleton formation; SRY-boxes (808 aa)
       
 
  0.566
DDX4
Probable ATP-dependent RNA helicase DDX4; ATP-dependent RNA helicase required during spermatogenesis. Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ ce [...] (724 aa)
     
   
  0.556
UBB
Polyubiquitin-B; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be involved in DNA repair; [...] (229 aa)
       
 
  0.550
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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