node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C17orf85 | ENSG00000257390 | ENSP00000373657 | ENSP00000447000 | Nuclear cap-binding protein subunit 3; Associates with NCBP1/CBP80 to form an alternative cap- binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress [...] | Uncharacterized protein | 0.528 |
CDC27 | ENSG00000257390 | ENSP00000434614 | ENSP00000447000 | Cell division cycle protein 27 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | Uncharacterized protein | 0.511 |
EID1 | ENSG00000257390 | ENSP00000431162 | ENSP00000447000 | EP300-interacting inhibitor of differentiation 1; Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms | Uncharacterized protein | 0.529 |
ENSG00000257390 | C17orf85 | ENSP00000447000 | ENSP00000373657 | Uncharacterized protein | Nuclear cap-binding protein subunit 3; Associates with NCBP1/CBP80 to form an alternative cap- binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress [...] | 0.528 |
ENSG00000257390 | CDC27 | ENSP00000447000 | ENSP00000434614 | Uncharacterized protein | Cell division cycle protein 27 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | 0.511 |
ENSG00000257390 | EID1 | ENSP00000447000 | ENSP00000431162 | Uncharacterized protein | EP300-interacting inhibitor of differentiation 1; Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms | 0.529 |
ENSG00000257390 | GIMAP8 | ENSP00000447000 | ENSP00000305107 | Uncharacterized protein | GTPase IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections; GTPases, IMAP | 0.524 |
ENSG00000257390 | SNRPD3 | ENSP00000447000 | ENSP00000215829 | Uncharacterized protein | Small nuclear ribonucleoprotein Sm D3; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3’-end processing | 0.558 |
ENSG00000257390 | TEX2 | ENSP00000447000 | ENSP00000258991 | Uncharacterized protein | Testis-expressed protein 2; Testis expressed 2 | 0.536 |
ENSG00000257390 | TOMM20 | ENSP00000447000 | ENSP00000355566 | Uncharacterized protein | Mitochondrial import receptor subunit TOM20 homolog; Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity); Belongs to the Tom20 family | 0.508 |
ENSG00000257390 | TOMM20L | ENSP00000447000 | ENSP00000354204 | Uncharacterized protein | TOMM20-like protein 1; Translocase of outer mitochondrial membrane 20 like | 0.508 |
ENSG00000257390 | UQCRH | ENSP00000447000 | ENSP00000309565 | Uncharacterized protein | Cytochrome b-c1 complex subunit 6, mitochondrial; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1; Belongs to the UQCRH/QCR6 family | 0.497 |
ENSG00000257390 | UQCRHL | ENSP00000447000 | ENSP00000485401 | Uncharacterized protein | Cytochrome b-c1 complex subunit 6-like, mitochondrial; May be a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 | 0.497 |
GIMAP8 | ENSG00000257390 | ENSP00000305107 | ENSP00000447000 | GTPase IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections; GTPases, IMAP | Uncharacterized protein | 0.524 |
SNRPD3 | ENSG00000257390 | ENSP00000215829 | ENSP00000447000 | Small nuclear ribonucleoprotein Sm D3; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3’-end processing | Uncharacterized protein | 0.558 |
TEX2 | ENSG00000257390 | ENSP00000258991 | ENSP00000447000 | Testis-expressed protein 2; Testis expressed 2 | Uncharacterized protein | 0.536 |
TOMM20 | ENSG00000257390 | ENSP00000355566 | ENSP00000447000 | Mitochondrial import receptor subunit TOM20 homolog; Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity); Belongs to the Tom20 family | Uncharacterized protein | 0.508 |
TOMM20 | TOMM20L | ENSP00000355566 | ENSP00000354204 | Mitochondrial import receptor subunit TOM20 homolog; Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity); Belongs to the Tom20 family | TOMM20-like protein 1; Translocase of outer mitochondrial membrane 20 like | 0.550 |
TOMM20 | UQCRH | ENSP00000355566 | ENSP00000309565 | Mitochondrial import receptor subunit TOM20 homolog; Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity); Belongs to the Tom20 family | Cytochrome b-c1 complex subunit 6, mitochondrial; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1; Belongs to the UQCRH/QCR6 family | 0.563 |
TOMM20 | UQCRHL | ENSP00000355566 | ENSP00000485401 | Mitochondrial import receptor subunit TOM20 homolog; Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity); Belongs to the Tom20 family | Cytochrome b-c1 complex subunit 6-like, mitochondrial; May be a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 | 0.506 |