DNAJC22 protein (human) - STRING database

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DNAJC22

DnaJ homolog subfamily C member 22; May function as a co-chaperone; DNAJ heat shock proteins (341 aa)

Predicted Functional Partners:

IKZF4

0.765

LMBR1L

0.722

DNAJC25

0.624

DNAJC10

0.624

DNAJC24

0.612

DNAJC28

0.604

DNAJC9

0.591

DNAJC1

0.591

SLC26A10

0.586

DNAJC17

0.581

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNAJC1	DNAJC22	ENSP00000366179	ENSP00000446830	DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins	DnaJ homolog subfamily C member 22; May function as a co-chaperone; DNAJ heat shock proteins	0.591
DNAJC1	DNAJC24	ENSP00000366179	ENSP00000417548	DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins	DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family	0.626
DNAJC1	DNAJC28	ENSP00000366179	ENSP00000479716	DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins	DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone; DNAJ heat shock proteins	0.641
DNAJC10	DNAJC22	ENSP00000264065	ENSP00000446830	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, [...]	DnaJ homolog subfamily C member 22; May function as a co-chaperone; DNAJ heat shock proteins	0.624
DNAJC10	DNAJC24	ENSP00000264065	ENSP00000417548	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, [...]	DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family	0.615
DNAJC10	DNAJC28	ENSP00000264065	ENSP00000479716	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, [...]	DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone; DNAJ heat shock proteins	0.612
DNAJC17	DNAJC22	ENSP00000220496	ENSP00000446830	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	DnaJ homolog subfamily C member 22; May function as a co-chaperone; DNAJ heat shock proteins	0.581
DNAJC17	DNAJC24	ENSP00000220496	ENSP00000417548	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family	0.580
DNAJC17	DNAJC25	ENSP00000220496	ENSP00000320650	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	DnaJ heat shock protein family member C25; Belongs to the DNAJC25 family	0.630
DNAJC17	DNAJC28	ENSP00000220496	ENSP00000479716	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone; DNAJ heat shock proteins	0.649
DNAJC22	DNAJC1	ENSP00000446830	ENSP00000366179	DnaJ homolog subfamily C member 22; May function as a co-chaperone; DNAJ heat shock proteins	DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins	0.591
DNAJC22	DNAJC10	ENSP00000446830	ENSP00000264065	DnaJ homolog subfamily C member 22; May function as a co-chaperone; DNAJ heat shock proteins	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, [...]	0.624
DNAJC22	DNAJC17	ENSP00000446830	ENSP00000220496	DnaJ homolog subfamily C member 22; May function as a co-chaperone; DNAJ heat shock proteins	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	0.581
DNAJC22	DNAJC24	ENSP00000446830	ENSP00000417548	DnaJ homolog subfamily C member 22; May function as a co-chaperone; DNAJ heat shock proteins	DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family	0.612
DNAJC22	DNAJC25	ENSP00000446830	ENSP00000320650	DnaJ homolog subfamily C member 22; May function as a co-chaperone; DNAJ heat shock proteins	DnaJ heat shock protein family member C25; Belongs to the DNAJC25 family	0.624
DNAJC22	DNAJC28	ENSP00000446830	ENSP00000479716	DnaJ homolog subfamily C member 22; May function as a co-chaperone; DNAJ heat shock proteins	DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone; DNAJ heat shock proteins	0.604
DNAJC22	DNAJC9	ENSP00000446830	ENSP00000362041	DnaJ homolog subfamily C member 22; May function as a co-chaperone; DNAJ heat shock proteins	DnaJ homolog subfamily C member 9; May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8; DNAJ heat shock proteins	0.591
DNAJC22	IKZF4	ENSP00000446830	ENSP00000262032	DnaJ homolog subfamily C member 22; May function as a co-chaperone; DNAJ heat shock proteins	Zinc finger protein Eos; DNA-binding protein that binds to the 5’GGGAATRCC-3’ Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T- cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity)	0.765
DNAJC22	LMBR1L	ENSP00000446830	ENSP00000267102	DnaJ homolog subfamily C member 22; May function as a co-chaperone; DNAJ heat shock proteins	Protein LMBR1L; Probable LCN1 receptor. May mediate LCN1 endocytosis	0.722
DNAJC22	SLC26A10	ENSP00000446830	ENSP00000320217	DnaJ homolog subfamily C member 22; May function as a co-chaperone; DNAJ heat shock proteins	Solute carrier family 26 member 10; Chloride/bicarbonate exchanger; Solute carriers	0.586

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