node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CACNA2D4 | CCDC178 | ENSP00000372169 | ENSP00000372576 | Voltage-dependent calcium channel subunit alpha-2/delta-4; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel; Calcium voltage-gated channel auxiliary alpha2delta subunits | Coiled-coil domain containing 178 | 0.429 |
CACNA2D4 | LRTM2 | ENSP00000372169 | ENSP00000446278 | Voltage-dependent calcium channel subunit alpha-2/delta-4; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel; Calcium voltage-gated channel auxiliary alpha2delta subunits | Leucine rich repeats and transmembrane domains 2 | 0.646 |
CCDC178 | CACNA2D4 | ENSP00000372576 | ENSP00000372169 | Coiled-coil domain containing 178 | Voltage-dependent calcium channel subunit alpha-2/delta-4; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel; Calcium voltage-gated channel auxiliary alpha2delta subunits | 0.429 |
CCDC178 | ESPNL | ENSP00000372576 | ENSP00000339115 | Coiled-coil domain containing 178 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; Ankyrin repeat domain containing | 0.557 |
CCDC178 | LRTM2 | ENSP00000372576 | ENSP00000446278 | Coiled-coil domain containing 178 | Leucine rich repeats and transmembrane domains 2 | 0.593 |
CNTNAP4 | HTR5A | ENSP00000479811 | ENSP00000287907 | Contactin-associated protein-like 4; Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system (By similarity) | 5-hydroxytryptamine receptor 5A; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins; 5-hydroxytryptamine receptors, G protein-coupled | 0.531 |
CNTNAP4 | LRTM2 | ENSP00000479811 | ENSP00000446278 | Contactin-associated protein-like 4; Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system (By similarity) | Leucine rich repeats and transmembrane domains 2 | 0.641 |
ESPNL | CCDC178 | ENSP00000339115 | ENSP00000372576 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; Ankyrin repeat domain containing | Coiled-coil domain containing 178 | 0.557 |
ESPNL | LRTM2 | ENSP00000339115 | ENSP00000446278 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; Ankyrin repeat domain containing | Leucine rich repeats and transmembrane domains 2 | 0.517 |
HTR5A | CNTNAP4 | ENSP00000287907 | ENSP00000479811 | 5-hydroxytryptamine receptor 5A; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins; 5-hydroxytryptamine receptors, G protein-coupled | Contactin-associated protein-like 4; Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system (By similarity) | 0.531 |
HTR5A | LRTM2 | ENSP00000287907 | ENSP00000446278 | 5-hydroxytryptamine receptor 5A; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins; 5-hydroxytryptamine receptors, G protein-coupled | Leucine rich repeats and transmembrane domains 2 | 0.520 |
IGSF8 | LRTM2 | ENSP00000357065 | ENSP00000446278 | Immunoglobulin superfamily member 8; May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility- suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin- dependent morphology and motility functions. May participate in the [...] | Leucine rich repeats and transmembrane domains 2 | 0.513 |
LPHN1 | LRTM2 | ENSP00000340688 | ENSP00000446278 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine rich repeats and transmembrane domains 2 | 0.685 |
LPHN2 | LRTM2 | ENSP00000322270 | ENSP00000446278 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Leucine rich repeats and transmembrane domains 2 | 0.685 |
LPHN3 | LRTM2 | ENSP00000422533 | ENSP00000446278 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Leucine rich repeats and transmembrane domains 2 | 0.685 |
LRTM2 | CACNA2D4 | ENSP00000446278 | ENSP00000372169 | Leucine rich repeats and transmembrane domains 2 | Voltage-dependent calcium channel subunit alpha-2/delta-4; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel; Calcium voltage-gated channel auxiliary alpha2delta subunits | 0.646 |
LRTM2 | CCDC178 | ENSP00000446278 | ENSP00000372576 | Leucine rich repeats and transmembrane domains 2 | Coiled-coil domain containing 178 | 0.593 |
LRTM2 | CNTNAP4 | ENSP00000446278 | ENSP00000479811 | Leucine rich repeats and transmembrane domains 2 | Contactin-associated protein-like 4; Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system (By similarity) | 0.641 |
LRTM2 | ESPNL | ENSP00000446278 | ENSP00000339115 | Leucine rich repeats and transmembrane domains 2 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; Ankyrin repeat domain containing | 0.517 |
LRTM2 | HTR5A | ENSP00000446278 | ENSP00000287907 | Leucine rich repeats and transmembrane domains 2 | 5-hydroxytryptamine receptor 5A; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins; 5-hydroxytryptamine receptors, G protein-coupled | 0.520 |