node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C12orf56 | DMXL1 | ENSP00000446101 | ENSP00000439479 | Uncharacterized protein C12orf56; Chromosome 12 open reading frame 56 | DmX-like protein 1; WD repeat domain containing | 0.424 |
C12orf56 | DTWD2 | ENSP00000446101 | ENSP00000425048 | Uncharacterized protein C12orf56; Chromosome 12 open reading frame 56 | DTW domain containing 2 | 0.631 |
C12orf56 | PAK7 | ENSP00000446101 | ENSP00000367686 | Uncharacterized protein C12orf56; Chromosome 12 open reading frame 56 | Serine/threonine-protein kinase PAK 5; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphoryla [...] | 0.429 |
C12orf56 | PLEKHO2 | ENSP00000446101 | ENSP00000326706 | Uncharacterized protein C12orf56; Chromosome 12 open reading frame 56 | Pleckstrin homology domain containing O2 | 0.634 |
C12orf56 | RASSF3 | ENSP00000446101 | ENSP00000443021 | Uncharacterized protein C12orf56; Chromosome 12 open reading frame 56 | Ras association domain family member 3 | 0.581 |
C12orf56 | TULP3 | ENSP00000446101 | ENSP00000380321 | Uncharacterized protein C12orf56; Chromosome 12 open reading frame 56 | Tubby-related protein 3; Negative regulator of the Shh signaling transduction pathway- recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein- coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT- A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis; Belongs to the TUB family | 0.507 |
C12orf56 | XPOT | ENSP00000446101 | ENSP00000327821 | Uncharacterized protein C12orf56; Chromosome 12 open reading frame 56 | Exportin-T; Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuc [...] | 0.503 |
DMXL1 | C12orf56 | ENSP00000439479 | ENSP00000446101 | DmX-like protein 1; WD repeat domain containing | Uncharacterized protein C12orf56; Chromosome 12 open reading frame 56 | 0.424 |
DMXL1 | DTWD2 | ENSP00000439479 | ENSP00000425048 | DmX-like protein 1; WD repeat domain containing | DTW domain containing 2 | 0.412 |
DTWD2 | C12orf56 | ENSP00000425048 | ENSP00000446101 | DTW domain containing 2 | Uncharacterized protein C12orf56; Chromosome 12 open reading frame 56 | 0.631 |
DTWD2 | DMXL1 | ENSP00000425048 | ENSP00000439479 | DTW domain containing 2 | DmX-like protein 1; WD repeat domain containing | 0.412 |
PAK7 | C12orf56 | ENSP00000367686 | ENSP00000446101 | Serine/threonine-protein kinase PAK 5; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphoryla [...] | Uncharacterized protein C12orf56; Chromosome 12 open reading frame 56 | 0.429 |
PLEKHO2 | C12orf56 | ENSP00000326706 | ENSP00000446101 | Pleckstrin homology domain containing O2 | Uncharacterized protein C12orf56; Chromosome 12 open reading frame 56 | 0.634 |
RASSF3 | C12orf56 | ENSP00000443021 | ENSP00000446101 | Ras association domain family member 3 | Uncharacterized protein C12orf56; Chromosome 12 open reading frame 56 | 0.581 |
RASSF3 | XPOT | ENSP00000443021 | ENSP00000327821 | Ras association domain family member 3 | Exportin-T; Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuc [...] | 0.641 |
TULP3 | C12orf56 | ENSP00000380321 | ENSP00000446101 | Tubby-related protein 3; Negative regulator of the Shh signaling transduction pathway- recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein- coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT- A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis; Belongs to the TUB family | Uncharacterized protein C12orf56; Chromosome 12 open reading frame 56 | 0.507 |
XPOT | C12orf56 | ENSP00000327821 | ENSP00000446101 | Exportin-T; Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuc [...] | Uncharacterized protein C12orf56; Chromosome 12 open reading frame 56 | 0.503 |
XPOT | RASSF3 | ENSP00000327821 | ENSP00000443021 | Exportin-T; Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuc [...] | Ras association domain family member 3 | 0.641 |