| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCBL2 | LYRM2 | ENSP00000260508 | ENSP00000430025 | Kynurenine--oxoglutarate transaminase 3; Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se- conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2- oxoglutarate as amino group acceptor (in vitro) (By s [...] | LYR motif containing 2 | 0.535 |
| CCBL2 | RBMXL1 | ENSP00000260508 | ENSP00000446099 | Kynurenine--oxoglutarate transaminase 3; Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se- conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2- oxoglutarate as amino group acceptor (in vitro) (By s [...] | RNA binding motif protein, X-linked-like-1; RNA-binding protein which may be involved in pre-mRNA splicing | 0.539 |
| CLK2 | NKTR | ENSP00000357345 | ENSP00000232978 | Dual specificity protein kinase CLK2; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphory [...] | NK-tumor recognition protein; Component of a putative tumor-recognition complex. Involved in the function of NK cells; Cyclophilin peptidylprolyl isomerases | 0.535 |
| CLK2 | RBMXL1 | ENSP00000357345 | ENSP00000446099 | Dual specificity protein kinase CLK2; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphory [...] | RNA binding motif protein, X-linked-like-1; RNA-binding protein which may be involved in pre-mRNA splicing | 0.635 |
| DMXL1 | NKTR | ENSP00000439479 | ENSP00000232978 | DmX-like protein 1; WD repeat domain containing | NK-tumor recognition protein; Component of a putative tumor-recognition complex. Involved in the function of NK cells; Cyclophilin peptidylprolyl isomerases | 0.680 |
| DMXL1 | RBMXL1 | ENSP00000439479 | ENSP00000446099 | DmX-like protein 1; WD repeat domain containing | RNA binding motif protein, X-linked-like-1; RNA-binding protein which may be involved in pre-mRNA splicing | 0.530 |
| LYRM2 | CCBL2 | ENSP00000430025 | ENSP00000260508 | LYR motif containing 2 | Kynurenine--oxoglutarate transaminase 3; Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se- conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2- oxoglutarate as amino group acceptor (in vitro) (By s [...] | 0.535 |
| LYRM2 | RBMXL1 | ENSP00000430025 | ENSP00000446099 | LYR motif containing 2 | RNA binding motif protein, X-linked-like-1; RNA-binding protein which may be involved in pre-mRNA splicing | 0.570 |
| NACA2 | RBMXL1 | ENSP00000427802 | ENSP00000446099 | Nascent polypeptide-associated complex subunit alpha-2; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity) | RNA binding motif protein, X-linked-like-1; RNA-binding protein which may be involved in pre-mRNA splicing | 0.569 |
| NKTR | CLK2 | ENSP00000232978 | ENSP00000357345 | NK-tumor recognition protein; Component of a putative tumor-recognition complex. Involved in the function of NK cells; Cyclophilin peptidylprolyl isomerases | Dual specificity protein kinase CLK2; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphory [...] | 0.535 |
| NKTR | DMXL1 | ENSP00000232978 | ENSP00000439479 | NK-tumor recognition protein; Component of a putative tumor-recognition complex. Involved in the function of NK cells; Cyclophilin peptidylprolyl isomerases | DmX-like protein 1; WD repeat domain containing | 0.680 |
| NKTR | RBMXL1 | ENSP00000232978 | ENSP00000446099 | NK-tumor recognition protein; Component of a putative tumor-recognition complex. Involved in the function of NK cells; Cyclophilin peptidylprolyl isomerases | RNA binding motif protein, X-linked-like-1; RNA-binding protein which may be involved in pre-mRNA splicing | 0.529 |
| RBMXL1 | CCBL2 | ENSP00000446099 | ENSP00000260508 | RNA binding motif protein, X-linked-like-1; RNA-binding protein which may be involved in pre-mRNA splicing | Kynurenine--oxoglutarate transaminase 3; Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se- conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2- oxoglutarate as amino group acceptor (in vitro) (By s [...] | 0.539 |
| RBMXL1 | CLK2 | ENSP00000446099 | ENSP00000357345 | RNA binding motif protein, X-linked-like-1; RNA-binding protein which may be involved in pre-mRNA splicing | Dual specificity protein kinase CLK2; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphory [...] | 0.635 |
| RBMXL1 | DMXL1 | ENSP00000446099 | ENSP00000439479 | RNA binding motif protein, X-linked-like-1; RNA-binding protein which may be involved in pre-mRNA splicing | DmX-like protein 1; WD repeat domain containing | 0.530 |
| RBMXL1 | LYRM2 | ENSP00000446099 | ENSP00000430025 | RNA binding motif protein, X-linked-like-1; RNA-binding protein which may be involved in pre-mRNA splicing | LYR motif containing 2 | 0.570 |
| RBMXL1 | NACA2 | ENSP00000446099 | ENSP00000427802 | RNA binding motif protein, X-linked-like-1; RNA-binding protein which may be involved in pre-mRNA splicing | Nascent polypeptide-associated complex subunit alpha-2; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity) | 0.569 |
| RBMXL1 | NKTR | ENSP00000446099 | ENSP00000232978 | RNA binding motif protein, X-linked-like-1; RNA-binding protein which may be involved in pre-mRNA splicing | NK-tumor recognition protein; Component of a putative tumor-recognition complex. Involved in the function of NK cells; Cyclophilin peptidylprolyl isomerases | 0.529 |
| RBMXL1 | SFPQ | ENSP00000446099 | ENSP00000349748 | RNA binding motif protein, X-linked-like-1; RNA-binding protein which may be involved in pre-mRNA splicing | Splicing factor, proline- and glutamine-rich; DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphory [...] | 0.549 |
| RBMXL1 | SYNCRIP | ENSP00000446099 | ENSP00000358635 | RNA binding motif protein, X-linked-like-1; RNA-binding protein which may be involved in pre-mRNA splicing | Heterogeneous nuclear ribonucleoprotein Q; Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD- mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 [...] | 0.718 |
