• Version:
  • 11.0 [archived version]
STRINGSTRING
DHRS2 DHRS2 UGT3A2 UGT3A2 SHD SHD ACOT11 ACOT11 CWC25 CWC25 KIAA0226L KIAA0226L LIX1 LIX1 C1orf109 C1orf109 CD300LG CD300LG UGT3A1 UGT3A1 SLCO1A2 SLCO1A2
"SHD" - SH2 domain-containing adapter protein D in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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SHDSH2 domain-containing adapter protein D; May function as an adapter protein; SH2 domain containing (340 aa)    
Predicted Functional Partners:
CWC25
CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex (425 aa)
     
        0.841
SLCO1A2
Solute carrier organic anion transporter family member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin; Solute carriers (670 aa)
     
        0.841
C1orf109
Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition (203 aa)
     
        0.840
LIX1
Protein limb expression 1 homolog; Limb and CNS expressed 1; Belongs to the LIX1 family (282 aa)
     
        0.840
KIAA0226L
Protein RUBCNL-like; May act as a tumor suppressor (662 aa)
     
        0.839
ACOT11
Acyl-coenzyme A thioesterase 11; Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (607 aa)
     
        0.839
CD300LG
CMRF35-like molecule 9; Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity); V-set domain containing (332 aa)
     
        0.822
DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial; Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21; Belongs to the short-chain dehydrogenases/reductases (SDR) family (300 aa)
     
   
  0.811
UGT3A2
UDP-glucuronosyltransferase 3A2; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity); Belongs to the UDP-glycosyltransferase family (523 aa)
     
        0.679
UGT3A1
UDP-glucuronosyltransferase 3A1; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity); Belongs to the UDP-glycosyltransferase family (523 aa)
     
        0.679
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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