KIAA1147 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

KIAA1147

Protein LCHN; May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (455 aa)

Predicted Functional Partners:

AVL9

0.925

FAM45A

0.907

DENND6A

0.907

DENND6B

0.710

SCAND1

0.584

UBTD2

0.581

RIC1

0.556

CCZ1

0.546

CCZ1B

0.546

KIAA2013

0.542

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AVL9	CCZ1	ENSP00000315568	ENSP00000325681	Late secretory pathway protein AVL9 homolog; Functions in cell migration	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated	0.587
AVL9	CCZ1B	ENSP00000315568	ENSP00000314544	Late secretory pathway protein AVL9 homolog; Functions in cell migration	CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated	0.587
AVL9	DENND6A	ENSP00000315568	ENSP00000311401	Late secretory pathway protein AVL9 homolog; Functions in cell migration	Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes; DENN/MADD domain containing	0.905
AVL9	DENND6B	ENSP00000315568	ENSP00000391524	Late secretory pathway protein AVL9 homolog; Functions in cell migration	Protein DENND6B; Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35; DENN/MADD domain containing	0.622
AVL9	FAM45A	ENSP00000315568	ENSP00000354688	Late secretory pathway protein AVL9 homolog; Functions in cell migration	Protein FAM45A; Family with sequence similarity 45 member A	0.905
AVL9	KIAA1147	ENSP00000315568	ENSP00000445768	Late secretory pathway protein AVL9 homolog; Functions in cell migration	Protein LCHN; May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia	0.925
AVL9	RIC1	ENSP00000315568	ENSP00000416696	Late secretory pathway protein AVL9 homolog; Functions in cell migration	RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1; WD repeat domain containing	0.633
CCZ1	AVL9	ENSP00000325681	ENSP00000315568	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated	Late secretory pathway protein AVL9 homolog; Functions in cell migration	0.587
CCZ1	FAM45A	ENSP00000325681	ENSP00000354688	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated	Protein FAM45A; Family with sequence similarity 45 member A	0.605
CCZ1	KIAA1147	ENSP00000325681	ENSP00000445768	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated	Protein LCHN; May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia	0.546
CCZ1	RIC1	ENSP00000325681	ENSP00000416696	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated	RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1; WD repeat domain containing	0.742
CCZ1B	AVL9	ENSP00000314544	ENSP00000315568	CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated	Late secretory pathway protein AVL9 homolog; Functions in cell migration	0.587
CCZ1B	FAM45A	ENSP00000314544	ENSP00000354688	CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated	Protein FAM45A; Family with sequence similarity 45 member A	0.605
CCZ1B	KIAA1147	ENSP00000314544	ENSP00000445768	CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated	Protein LCHN; May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia	0.546
CCZ1B	RIC1	ENSP00000314544	ENSP00000416696	CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated	RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1; WD repeat domain containing	0.742
DENND6A	AVL9	ENSP00000311401	ENSP00000315568	Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes; DENN/MADD domain containing	Late secretory pathway protein AVL9 homolog; Functions in cell migration	0.905
DENND6A	FAM45A	ENSP00000311401	ENSP00000354688	Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes; DENN/MADD domain containing	Protein FAM45A; Family with sequence similarity 45 member A	0.909
DENND6A	KIAA1147	ENSP00000311401	ENSP00000445768	Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes; DENN/MADD domain containing	Protein LCHN; May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia	0.907
DENND6B	AVL9	ENSP00000391524	ENSP00000315568	Protein DENND6B; Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35; DENN/MADD domain containing	Late secretory pathway protein AVL9 homolog; Functions in cell migration	0.622
DENND6B	FAM45A	ENSP00000391524	ENSP00000354688	Protein DENND6B; Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35; DENN/MADD domain containing	Protein FAM45A; Family with sequence similarity 45 member A	0.743

page 1 of 3

Network

Cooccurrence

Textmining

Coexpression

Experiments

Neighborhood

Databases

Fusion

© STRING Consortium 2020

Credits

Access

Info

About