| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CASP9 | FBXW5 | ENSP00000330237 | ENSP00000313034 | Caspase-9; Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP); Apoptosome | F-box/WD repeat-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1- F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes re [...] | 0.541 |
| CASP9 | TNFAIP8L1 | ENSP00000330237 | ENSP00000444215 | Caspase-9; Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP); Apoptosome | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity; Belongs to the TNFAIP8 family | 0.478 |
| CCNYL1 | RBBP9 | ENSP00000342344 | ENSP00000336866 | Cyclin-Y-like protein 1; Cyclin Y like 1; Belongs to the cyclin family | Putative hydrolase RBBP9; May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1; Belongs to the RBBP9 family | 0.423 |
| CCNYL1 | TNFAIP8L1 | ENSP00000342344 | ENSP00000444215 | Cyclin-Y-like protein 1; Cyclin Y like 1; Belongs to the cyclin family | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity; Belongs to the TNFAIP8 family | 0.505 |
| CTRP5 | TNFAIP8L1 | ENSP00000431140 | ENSP00000444215 | Complement C1q tumor necrosis factor-related protein 5; C1q and TNF related 5 | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity; Belongs to the TNFAIP8 family | 0.451 |
| FBXW5 | CASP9 | ENSP00000313034 | ENSP00000330237 | F-box/WD repeat-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1- F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes re [...] | Caspase-9; Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP); Apoptosome | 0.541 |
| FBXW5 | TNFAIP8L1 | ENSP00000313034 | ENSP00000444215 | F-box/WD repeat-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1- F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes re [...] | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity; Belongs to the TNFAIP8 family | 0.819 |
| HTATIP2 | TNFAIP8L1 | ENSP00000392985 | ENSP00000444215 | Oxidoreductase HTATIP2; Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect; Short chain dehydrogenase/reductase superfamily | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity; Belongs to the TNFAIP8 family | 0.470 |
| NDUFS5 | TNFAIP8L1 | ENSP00000362060 | ENSP00000444215 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity; Belongs to the TNFAIP8 family | 0.777 |
| PRR16 | SCNM1 | ENSP00000385118 | ENSP00000357901 | Protein Largen; Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration | Sodium channel modifier 1; Plays a role in RNA splicing, possibly contributing to the recognition of non-consensus donor sites | 0.643 |
| PRR16 | TNFAIP8L1 | ENSP00000385118 | ENSP00000444215 | Protein Largen; Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity; Belongs to the TNFAIP8 family | 0.621 |
| RBBP9 | CCNYL1 | ENSP00000336866 | ENSP00000342344 | Putative hydrolase RBBP9; May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1; Belongs to the RBBP9 family | Cyclin-Y-like protein 1; Cyclin Y like 1; Belongs to the cyclin family | 0.423 |
| RBBP9 | TNFAIP8L1 | ENSP00000336866 | ENSP00000444215 | Putative hydrolase RBBP9; May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1; Belongs to the RBBP9 family | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity; Belongs to the TNFAIP8 family | 0.485 |
| SCNM1 | PRR16 | ENSP00000357901 | ENSP00000385118 | Sodium channel modifier 1; Plays a role in RNA splicing, possibly contributing to the recognition of non-consensus donor sites | Protein Largen; Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration | 0.643 |
| SCNM1 | TNFAIP8L1 | ENSP00000357901 | ENSP00000444215 | Sodium channel modifier 1; Plays a role in RNA splicing, possibly contributing to the recognition of non-consensus donor sites | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity; Belongs to the TNFAIP8 family | 0.592 |
| SMIM12 | TNFAIP8L1 | ENSP00000428585 | ENSP00000444215 | Small integral membrane protein 12 | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity; Belongs to the TNFAIP8 family | 0.446 |
| TNFAIP8L1 | CASP9 | ENSP00000444215 | ENSP00000330237 | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity; Belongs to the TNFAIP8 family | Caspase-9; Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP); Apoptosome | 0.478 |
| TNFAIP8L1 | CCNYL1 | ENSP00000444215 | ENSP00000342344 | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity; Belongs to the TNFAIP8 family | Cyclin-Y-like protein 1; Cyclin Y like 1; Belongs to the cyclin family | 0.505 |
| TNFAIP8L1 | CTRP5 | ENSP00000444215 | ENSP00000431140 | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity; Belongs to the TNFAIP8 family | Complement C1q tumor necrosis factor-related protein 5; C1q and TNF related 5 | 0.451 |
| TNFAIP8L1 | FBXW5 | ENSP00000444215 | ENSP00000313034 | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity; Belongs to the TNFAIP8 family | F-box/WD repeat-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1- F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes re [...] | 0.819 |
