node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COL4A6 | DCN | ENSP00000378340 | ENSP00000052754 | Collagen alpha-6(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | 0.457 |
COL4A6 | PDGFRL | ENSP00000378340 | ENSP00000444211 | Collagen alpha-6(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like; I-set domain containing | 0.523 |
DCN | COL4A6 | ENSP00000052754 | ENSP00000378340 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Collagen alpha-6(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.457 |
DCN | PDGFRL | ENSP00000052754 | ENSP00000444211 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like; I-set domain containing | 0.501 |
FERMT3 | PDGFRL | ENSP00000279227 | ENSP00000444211 | Fermitin family homolog 3; Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity); Belongs to the kindlin family | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like; I-set domain containing | 0.644 |
FERMT3 | SCRIB | ENSP00000279227 | ENSP00000349486 | Fermitin family homolog 3; Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity); Belongs to the kindlin family | Protein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicle [...] | 0.628 |
GDPD3 | PDGFRL | ENSP00000384363 | ENSP00000444211 | Lysophospholipase D GDPD3; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) and lysophosphatidylcholine (lyso-PC), and to a lesser extent for lysophosphatidylethanolamine (lyso-PE). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like; I-set domain containing | 0.497 |
GDPD3 | SPINK2 | ENSP00000384363 | ENSP00000425961 | Lysophospholipase D GDPD3; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) and lysophosphatidylcholine (lyso-PC), and to a lesser extent for lysophosphatidylethanolamine (lyso-PE). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine | Serine peptidase inhibitor, Kazal type 2 | 0.603 |
MOSPD1 | PDGFRL | ENSP00000359819 | ENSP00000444211 | Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to- mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like; I-set domain containing | 0.594 |
PDGFRL | COL4A6 | ENSP00000444211 | ENSP00000378340 | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like; I-set domain containing | Collagen alpha-6(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.523 |
PDGFRL | DCN | ENSP00000444211 | ENSP00000052754 | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like; I-set domain containing | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | 0.501 |
PDGFRL | FERMT3 | ENSP00000444211 | ENSP00000279227 | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like; I-set domain containing | Fermitin family homolog 3; Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity); Belongs to the kindlin family | 0.644 |
PDGFRL | GDPD3 | ENSP00000444211 | ENSP00000384363 | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like; I-set domain containing | Lysophospholipase D GDPD3; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) and lysophosphatidylcholine (lyso-PC), and to a lesser extent for lysophosphatidylethanolamine (lyso-PE). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine | 0.497 |
PDGFRL | MOSPD1 | ENSP00000444211 | ENSP00000359819 | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like; I-set domain containing | Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to- mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation | 0.594 |
PDGFRL | ROR1 | ENSP00000444211 | ENSP00000360120 | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like; I-set domain containing | Inactive tyrosine-protein kinase transmembrane receptor ROR1; Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells; I-set domain containing | 0.596 |
PDGFRL | SCRIB | ENSP00000444211 | ENSP00000349486 | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like; I-set domain containing | Protein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicle [...] | 0.668 |
PDGFRL | SPINK2 | ENSP00000444211 | ENSP00000425961 | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like; I-set domain containing | Serine peptidase inhibitor, Kazal type 2 | 0.495 |
PDGFRL | TUSC3 | ENSP00000444211 | ENSP00000424544 | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like; I-set domain containing | Tumor suppressor candidate 3; Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfide [...] | 0.907 |
PDGFRL | UCMA | ENSP00000444211 | ENSP00000367952 | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like; I-set domain containing | Unique cartilage matrix-associated protein; May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface | 0.547 |
ROR1 | PDGFRL | ENSP00000360120 | ENSP00000444211 | Inactive tyrosine-protein kinase transmembrane receptor ROR1; Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells; I-set domain containing | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like; I-set domain containing | 0.596 |