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  • 11.0 [archived version]
STRINGSTRING
NKAIN1 NKAIN1 CDC42SE2 CDC42SE2 CAPSL CAPSL CRYM CRYM DEPDC1B DEPDC1B LMBRD2 LMBRD2 RAI2 RAI2 SIVA1 SIVA1 CDKL5 CDKL5 REPS2 REPS2 NHS NHS
"RAI2" - Retinoic acid induced 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
RAI2Retinoic acid induced 2 (530 aa)    
Predicted Functional Partners:
NHS
Nance-Horan syndrome protein; May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development; Belongs to the NHS family (1630 aa)
      
   
  0.941
LMBRD2
LMBR1 domain containing 2 (695 aa)
            
  0.724
CDKL5
Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2; Cilia and flagella associated (1030 aa)
      
   
  0.713
SIVA1
Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa- B and promotes T-cell receptor-mediated apoptosis (175 aa)
            
  0.709
CAPSL
Calcyphosin-like protein; EF-hand domain containing (208 aa)
            
  0.696
DEPDC1B
DEP domain containing 1B (529 aa)
            
  0.690
REPS2
RalBP1-associated Eps domain-containing protein 2; Involved in growth factor signaling through its influence on the Ral signaling pathway; EF-hand domain containing (660 aa)
      
   
  0.633
CRYM
Ketimine reductase mu-crystallin; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors (314 aa)
      
   
  0.618
CDC42SE2
CDC42 small effector protein 2; Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages; Belongs to the CDC42SE/SPEC family (84 aa)
      
   
  0.595
NKAIN1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1; Sodium/potassium transporting ATPase interacting 1 (207 aa)
            
  0.568
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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