| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CYLC1 | FAM46D | ENSP00000331556 | ENSP00000443410 | Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation | Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase | 0.675 |
| CYLC1 | RPS6KA6 | ENSP00000331556 | ENSP00000262752 | Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation | Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily | 0.819 |
| FAM133A | FAM46D | ENSP00000318974 | ENSP00000443410 | Protein FAM133A; Family with sequence similarity 133 member A | Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase | 0.686 |
| FAM133A | IL13RA1 | ENSP00000318974 | ENSP00000360730 | Protein FAM133A; Family with sequence similarity 133 member A | Interleukin-13 receptor subunit alpha-1; Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity; Belongs to the type I cytokine receptor family. Type 5 subfamily | 0.455 |
| FAM46D | CYLC1 | ENSP00000443410 | ENSP00000331556 | Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase | Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation | 0.675 |
| FAM46D | FAM133A | ENSP00000443410 | ENSP00000318974 | Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase | Protein FAM133A; Family with sequence similarity 133 member A | 0.686 |
| FAM46D | HDX | ENSP00000443410 | ENSP00000297977 | Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase | Highly divergent homeobox; POU class homeoboxes and pseudogenes | 0.673 |
| FAM46D | HEY1 | ENSP00000443410 | ENSP00000338272 | Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5’-CACGTG-3’. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...] | 0.747 |
| FAM46D | IL13RA1 | ENSP00000443410 | ENSP00000360730 | Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase | Interleukin-13 receptor subunit alpha-1; Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity; Belongs to the type I cytokine receptor family. Type 5 subfamily | 0.712 |
| FAM46D | MAB21L3 | ENSP00000443410 | ENSP00000358512 | Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase | Protein mab-21-like 3; Mab-21 like 3 | 0.691 |
| FAM46D | MB21D2 | ENSP00000443410 | ENSP00000376246 | Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase | Protein MB21D2; Mab-21 domain containing 2 | 0.729 |
| FAM46D | PAPOLG | ENSP00000443410 | ENSP00000238714 | Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase | Poly(A) polymerase gamma; Responsible for the post-transcriptional adenylation of the 3’-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA | 0.650 |
| FAM46D | RPS6KA6 | ENSP00000443410 | ENSP00000262752 | Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase | Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily | 0.678 |
| FAM46D | TAMM41 | ENSP00000443410 | ENSP00000398596 | Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase | Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane (By similarity); Belongs to the TAM41 family | 0.678 |
| HDX | FAM46D | ENSP00000297977 | ENSP00000443410 | Highly divergent homeobox; POU class homeoboxes and pseudogenes | Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase | 0.673 |
| HDX | RPS6KA6 | ENSP00000297977 | ENSP00000262752 | Highly divergent homeobox; POU class homeoboxes and pseudogenes | Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily | 0.654 |
| HEY1 | FAM46D | ENSP00000338272 | ENSP00000443410 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5’-CACGTG-3’. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...] | Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase | 0.747 |
| IL13RA1 | FAM133A | ENSP00000360730 | ENSP00000318974 | Interleukin-13 receptor subunit alpha-1; Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity; Belongs to the type I cytokine receptor family. Type 5 subfamily | Protein FAM133A; Family with sequence similarity 133 member A | 0.455 |
| IL13RA1 | FAM46D | ENSP00000360730 | ENSP00000443410 | Interleukin-13 receptor subunit alpha-1; Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity; Belongs to the type I cytokine receptor family. Type 5 subfamily | Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase | 0.712 |
| MAB21L3 | FAM46D | ENSP00000358512 | ENSP00000443410 | Protein mab-21-like 3; Mab-21 like 3 | Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase | 0.691 |
