| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALOX15B | FAM180B | ENSP00000369530 | ENSP00000443133 | Arachidonate 15-lipoxygenase B; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)- HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by m [...] | Protein FAM180B; Family with sequence similarity 180 member B | 0.432 |
| C1QTNF4 | FAM180B | ENSP00000302274 | ENSP00000443133 | Complement C1q tumor necrosis factor-related protein 4; May act as a pro-inflammatory cytokine, that induces the activation of NF-kappa-B signaling pathway and up-regulates IL6 production; C1q and TNF related | Protein FAM180B; Family with sequence similarity 180 member B | 0.447 |
| C1QTNF4 | KBTBD4 | ENSP00000302274 | ENSP00000415106 | Complement C1q tumor necrosis factor-related protein 4; May act as a pro-inflammatory cytokine, that induces the activation of NF-kappa-B signaling pathway and up-regulates IL6 production; C1q and TNF related | Kelch repeat and BTB domain containing 4 | 0.447 |
| C1QTNF4 | ZCWPW1 | ENSP00000302274 | ENSP00000381109 | Complement C1q tumor necrosis factor-related protein 4; May act as a pro-inflammatory cytokine, that induces the activation of NF-kappa-B signaling pathway and up-regulates IL6 production; C1q and TNF related | Zinc finger CW-type and PWWP domain containing 1 | 0.472 |
| CHIT1 | FAM180B | ENSP00000356198 | ENSP00000443133 | Chitotriosidase-1; Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity; Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily | Protein FAM180B; Family with sequence similarity 180 member B | 0.458 |
| ENSG00000272752 | FAM180B | ENSP00000410764 | ENSP00000443133 | Paired immunoglobulin-like type 2 receptor beta; Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface | Protein FAM180B; Family with sequence similarity 180 member B | 0.416 |
| ENSG00000272752 | KBTBD4 | ENSP00000410764 | ENSP00000415106 | Paired immunoglobulin-like type 2 receptor beta; Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface | Kelch repeat and BTB domain containing 4 | 0.414 |
| ENSG00000272752 | NYAP1 | ENSP00000410764 | ENSP00000300179 | Paired immunoglobulin-like type 2 receptor beta; Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1; Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis; Belongs to the NYAP family | 0.520 |
| ENSG00000272752 | ZCWPW1 | ENSP00000410764 | ENSP00000381109 | Paired immunoglobulin-like type 2 receptor beta; Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface | Zinc finger CW-type and PWWP domain containing 1 | 0.589 |
| FAM180B | ALOX15B | ENSP00000443133 | ENSP00000369530 | Protein FAM180B; Family with sequence similarity 180 member B | Arachidonate 15-lipoxygenase B; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)- HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by m [...] | 0.432 |
| FAM180B | C1QTNF4 | ENSP00000443133 | ENSP00000302274 | Protein FAM180B; Family with sequence similarity 180 member B | Complement C1q tumor necrosis factor-related protein 4; May act as a pro-inflammatory cytokine, that induces the activation of NF-kappa-B signaling pathway and up-regulates IL6 production; C1q and TNF related | 0.447 |
| FAM180B | CHIT1 | ENSP00000443133 | ENSP00000356198 | Protein FAM180B; Family with sequence similarity 180 member B | Chitotriosidase-1; Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity; Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily | 0.458 |
| FAM180B | ENSG00000272752 | ENSP00000443133 | ENSP00000410764 | Protein FAM180B; Family with sequence similarity 180 member B | Paired immunoglobulin-like type 2 receptor beta; Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface | 0.416 |
| FAM180B | KBTBD4 | ENSP00000443133 | ENSP00000415106 | Protein FAM180B; Family with sequence similarity 180 member B | Kelch repeat and BTB domain containing 4 | 0.551 |
| FAM180B | MICAL2 | ENSP00000443133 | ENSP00000256194 | Protein FAM180B; Family with sequence similarity 180 member B | [F-actin]-monooxygenase MICAL2; Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum- mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promot [...] | 0.552 |
| FAM180B | NYAP1 | ENSP00000443133 | ENSP00000300179 | Protein FAM180B; Family with sequence similarity 180 member B | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1; Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis; Belongs to the NYAP family | 0.632 |
| FAM180B | SLC39A13 | ENSP00000443133 | ENSP00000354689 | Protein FAM180B; Family with sequence similarity 180 member B | Zinc transporter ZIP13; Acts as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family | 0.449 |
| FAM180B | TMEM91 | ENSP00000443133 | ENSP00000375859 | Protein FAM180B; Family with sequence similarity 180 member B | Interferon induced transmembrane protein domain containing; Belongs to the CD225/Dispanin family | 0.519 |
| FAM180B | ZCWPW1 | ENSP00000443133 | ENSP00000381109 | Protein FAM180B; Family with sequence similarity 180 member B | Zinc finger CW-type and PWWP domain containing 1 | 0.456 |
| KBTBD4 | C1QTNF4 | ENSP00000415106 | ENSP00000302274 | Kelch repeat and BTB domain containing 4 | Complement C1q tumor necrosis factor-related protein 4; May act as a pro-inflammatory cytokine, that induces the activation of NF-kappa-B signaling pathway and up-regulates IL6 production; C1q and TNF related | 0.447 |
