| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AK7 | ASIC5 | ENSP00000267584 | ENSP00000442477 | Adenylate kinase 7; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function; In the C-terminal section; belongs to the dpy-30 family | Acid-sensing ion channel 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily | 0.472 |
| ASIC5 | AK7 | ENSP00000442477 | ENSP00000267584 | Acid-sensing ion channel 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily | Adenylate kinase 7; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function; In the C-terminal section; belongs to the dpy-30 family | 0.472 |
| ASIC5 | CTSO | ENSP00000442477 | ENSP00000414904 | Acid-sensing ion channel 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily | Cathepsin O; Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover; Belongs to the peptidase C1 family | 0.581 |
| ASIC5 | NCR1 | ENSP00000442477 | ENSP00000291890 | Acid-sensing ion channel 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily | Natural cytotoxicity triggering receptor 1; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis | 0.591 |
| ASIC5 | NCR2 | ENSP00000442477 | ENSP00000362181 | Acid-sensing ion channel 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily | Natural cytotoxicity triggering receptor 2; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis | 0.440 |
| ASIC5 | RBM46 | ENSP00000442477 | ENSP00000281722 | Acid-sensing ion channel 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily | Probable RNA-binding protein 46; RNA binding motif containing | 0.471 |
| ASIC5 | SHISA5 | ENSP00000442477 | ENSP00000296444 | Acid-sensing ion channel 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily | Protein shisa-5; Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis; Shisa family members | 0.462 |
| ASIC5 | SLC10A2 | ENSP00000442477 | ENSP00000245312 | Acid-sensing ion channel 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily | Ileal sodium/bile acid cotransporter; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism; Belongs to the bile acid-sodium symporter (BASS) (TC 2.A.28) family | 0.509 |
| ASIC5 | SLC5A1 | ENSP00000442477 | ENSP00000266088 | Acid-sensing ion channel 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily | Sodium/glucose cotransporter 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2-1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules; Solute carriers | 0.448 |
| ASIC5 | STOM | ENSP00000442477 | ENSP00000286713 | Acid-sensing ion channel 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily | Erythrocyte band 7 integral membrane protein; Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity; Belongs to the band 7/mec-2 family | 0.905 |
| ASIC5 | STOML3 | ENSP00000442477 | ENSP00000368952 | Acid-sensing ion channel 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily | Stomatin-like protein 3; Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations | 0.911 |
| CTSO | ASIC5 | ENSP00000414904 | ENSP00000442477 | Cathepsin O; Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover; Belongs to the peptidase C1 family | Acid-sensing ion channel 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily | 0.581 |
| CTSO | RBM46 | ENSP00000414904 | ENSP00000281722 | Cathepsin O; Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover; Belongs to the peptidase C1 family | Probable RNA-binding protein 46; RNA binding motif containing | 0.400 |
| NCR1 | ASIC5 | ENSP00000291890 | ENSP00000442477 | Natural cytotoxicity triggering receptor 1; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis | Acid-sensing ion channel 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily | 0.591 |
| NCR1 | NCR2 | ENSP00000291890 | ENSP00000362181 | Natural cytotoxicity triggering receptor 1; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis | Natural cytotoxicity triggering receptor 2; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis | 0.920 |
| NCR2 | ASIC5 | ENSP00000362181 | ENSP00000442477 | Natural cytotoxicity triggering receptor 2; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis | Acid-sensing ion channel 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily | 0.440 |
| NCR2 | NCR1 | ENSP00000362181 | ENSP00000291890 | Natural cytotoxicity triggering receptor 2; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis | Natural cytotoxicity triggering receptor 1; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis | 0.920 |
| RBM46 | ASIC5 | ENSP00000281722 | ENSP00000442477 | Probable RNA-binding protein 46; RNA binding motif containing | Acid-sensing ion channel 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily | 0.471 |
| RBM46 | CTSO | ENSP00000281722 | ENSP00000414904 | Probable RNA-binding protein 46; RNA binding motif containing | Cathepsin O; Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover; Belongs to the peptidase C1 family | 0.400 |
| SHISA5 | ASIC5 | ENSP00000296444 | ENSP00000442477 | Protein shisa-5; Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis; Shisa family members | Acid-sensing ion channel 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily | 0.462 |
