• Version:
  • 11.0 [archived version]
STRINGSTRING
PWWP2B PWWP2B POGZ POGZ TRIP12 TRIP12 HDGFL1 HDGFL1 UBQLNL UBQLNL TKTL2 TKTL2 ZSWIM6 ZSWIM6 ACTL7A ACTL7A KIF2B KIF2B FTMT FTMT CCIN CCIN
"HDGFL1" - Hepatoma-derived growth factor-like protein 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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[Homology]
Score
HDGFL1Hepatoma-derived growth factor-like protein 1; Heparin binding growth factor family; Belongs to the HDGF family (251 aa)    
Predicted Functional Partners:
POGZ
Pogo transposable element with ZNF domain; Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms; DNA transposon derived genes (1410 aa)
       
 
  0.698
UBQLNL
Ubiquilin-like protein; Ubiquilin family (475 aa)
           
  0.690
ACTL7A
Actin-like protein 7A; Actin related proteins; Belongs to the actin family (435 aa)
           
  0.680
TRIP12
E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in [...] (2040 aa)
     
        0.670
PWWP2B
PWWP domain containing 2B (590 aa)
           
  0.670
ZSWIM6
Zinc finger SWIM-type containing 6 (1215 aa)
           
  0.577
CCIN
Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation; BTB domain containing (588 aa)
           
  0.573
FTMT
Ferritin, mitochondrial; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation; Ferritin subunits (242 aa)
           
  0.557
TKTL2
Transketolase-like protein 2; Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis; Belongs to the transketolase family (626 aa)
           
  0.542
KIF2B
Kinesin-like protein KIF2B; Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity. Plays a role in chromosome congression; Kinesins (673 aa)
     
   
  0.519
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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