| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DENND2C | SYCE1L | ENSP00000376955 | ENSP00000367911 | DENN domain-containing protein 2C; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form; DENN/MADD domain containing | Synaptonemal complex central element protein 1-like; May be involved in meiosis | 0.474 |
| DENND2C | ZNF567 | ENSP00000376955 | ENSP00000441838 | DENN domain-containing protein 2C; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form; DENN/MADD domain containing | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.510 |
| ETFB | N4BP2 | ENSP00000346173 | ENSP00000261435 | Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role | NEDD4-binding protein 2; Has 5’-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination | 0.544 |
| ETFB | PRDX6 | ENSP00000346173 | ENSP00000342026 | Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] | 0.638 |
| ETFB | ZNF567 | ENSP00000346173 | ENSP00000441838 | Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.647 |
| ETFB | ZWILCH | ENSP00000346173 | ENSP00000311429 | Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role | Protein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex; Belongs to the ZWILCH family | 0.658 |
| MALT1 | ZAK | ENSP00000319279 | ENSP00000364361 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1; Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion; Belongs to the peptidase C14B family | Mitogen-activated protein kinase kinase kinase 20; Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Involved in limb development | 0.407 |
| MALT1 | ZNF567 | ENSP00000319279 | ENSP00000441838 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1; Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion; Belongs to the peptidase C14B family | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.686 |
| N4BP2 | ETFB | ENSP00000261435 | ENSP00000346173 | NEDD4-binding protein 2; Has 5’-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination | Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role | 0.544 |
| N4BP2 | PRDX6 | ENSP00000261435 | ENSP00000342026 | NEDD4-binding protein 2; Has 5’-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] | 0.484 |
| N4BP2 | ZNF567 | ENSP00000261435 | ENSP00000441838 | NEDD4-binding protein 2; Has 5’-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.579 |
| N4BP2 | ZWILCH | ENSP00000261435 | ENSP00000311429 | NEDD4-binding protein 2; Has 5’-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination | Protein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex; Belongs to the ZWILCH family | 0.545 |
| PRDX6 | ETFB | ENSP00000342026 | ENSP00000346173 | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] | Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role | 0.638 |
| PRDX6 | N4BP2 | ENSP00000342026 | ENSP00000261435 | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] | NEDD4-binding protein 2; Has 5’-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination | 0.484 |
| PRDX6 | ZNF567 | ENSP00000342026 | ENSP00000441838 | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.626 |
| PRDX6 | ZWILCH | ENSP00000342026 | ENSP00000311429 | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] | Protein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex; Belongs to the ZWILCH family | 0.629 |
| RELL1 | SYCE1L | ENSP00000398778 | ENSP00000367911 | RELT-like protein 1; RELT family; Belongs to the RELT family | Synaptonemal complex central element protein 1-like; May be involved in meiosis | 0.475 |
| RELL1 | ZNF567 | ENSP00000398778 | ENSP00000441838 | RELT-like protein 1; RELT family; Belongs to the RELT family | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.511 |
| SYCE1L | DENND2C | ENSP00000367911 | ENSP00000376955 | Synaptonemal complex central element protein 1-like; May be involved in meiosis | DENN domain-containing protein 2C; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form; DENN/MADD domain containing | 0.474 |
| SYCE1L | RELL1 | ENSP00000367911 | ENSP00000398778 | Synaptonemal complex central element protein 1-like; May be involved in meiosis | RELT-like protein 1; RELT family; Belongs to the RELT family | 0.475 |
