• Version:
  • 11.0 [archived version]
STRINGSTRING
GPR31 GPR31 GPR22 GPR22 GPR82 GPR82 ACTR10 ACTR10 GPR19 GPR19 DGKD DGKD HSPA13 HSPA13 TTC18 TTC18 FHAD1 FHAD1 SLC35F4 SLC35F4 DHX40 DHX40
"GPR19" - Probable G-protein coupled receptor 19 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GPR19Probable G-protein coupled receptor 19; Orphan receptor; G protein-coupled receptors, Class A orphans (415 aa)    
Predicted Functional Partners:
HSPA13
Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins (471 aa)
       
 
  0.626
SLC35F4
Solute carrier family 35 member F4; Putative solute transporter (521 aa)
           
  0.624
TTC18
Cilia- and flagella-associated protein 70; Tetratricopeptide repeat domain 18; Belongs to the CFAP70 family (1121 aa)
           
  0.624
DHX40
Probable ATP-dependent RNA helicase DHX40; Probable ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily (779 aa)
           
  0.624
DGKD
Diacylglycerol kinase delta; May function as signaling molecule; Diacylglycerol kinases (1214 aa)
           
  0.600
FHAD1
Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1 (1412 aa)
           
  0.545
ACTR10
Actin related protein 10 homolog; Belongs to the actin family (417 aa)
           
  0.544
GPR82
Probable G-protein coupled receptor 82; Orphan receptor; G protein-coupled receptors, Class A orphans (336 aa)
           
  0.525
GPR22
Probable G-protein coupled receptor 22; Orphan receptor; G protein-coupled receptors, Class A orphans (433 aa)
           
  0.512
GPR31
12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B; G protein-coupled receptors, Class A orphans (319 aa)
           
  0.474
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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