| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABCD4 | NOX3 | ENSP00000349396 | ENSP00000159060 | ATP-binding cassette sub-family D member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm; ATP binding cassette subfamily D | NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity | 0.471 |
| ABCD4 | SALL3 | ENSP00000349396 | ENSP00000441823 | ATP-binding cassette sub-family D member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm; ATP binding cassette subfamily D | Sal-like protein 3; Probable transcription factor; Zinc fingers C2H2-type | 0.657 |
| CD38 | COQ2 | ENSP00000226279 | ENSP00000310873 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system; Belongs to the ADP-ribosyl cyclase family | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate | 0.469 |
| CD38 | SALL3 | ENSP00000226279 | ENSP00000441823 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system; Belongs to the ADP-ribosyl cyclase family | Sal-like protein 3; Probable transcription factor; Zinc fingers C2H2-type | 0.641 |
| COQ2 | CD38 | ENSP00000310873 | ENSP00000226279 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system; Belongs to the ADP-ribosyl cyclase family | 0.469 |
| COQ2 | SALL3 | ENSP00000310873 | ENSP00000441823 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate | Sal-like protein 3; Probable transcription factor; Zinc fingers C2H2-type | 0.901 |
| DNMT3A | SALL3 | ENSP00000264709 | ENSP00000441823 | DNA (cytosine-5)-methyltransferase 3A; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimet [...] | Sal-like protein 3; Probable transcription factor; Zinc fingers C2H2-type | 0.711 |
| DNMT3A | SOX2 | ENSP00000264709 | ENSP00000323588 | DNA (cytosine-5)-methyltransferase 3A; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimet [...] | Transcription factor SOX-2; Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By si [...] | 0.533 |
| DSCAML1 | SALL3 | ENSP00000315465 | ENSP00000441823 | Down syndrome cell adhesion molecule-like protein 1; Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina- expressed in specific subsets of interneurons and retinal [...] | Sal-like protein 3; Probable transcription factor; Zinc fingers C2H2-type | 0.486 |
| FOXI2 | NOX3 | ENSP00000373572 | ENSP00000159060 | Forkhead box protein I2; Possible transcriptional activator; Forkhead boxes | NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity | 0.408 |
| FOXI2 | SALL3 | ENSP00000373572 | ENSP00000441823 | Forkhead box protein I2; Possible transcriptional activator; Forkhead boxes | Sal-like protein 3; Probable transcription factor; Zinc fingers C2H2-type | 0.483 |
| NOX3 | ABCD4 | ENSP00000159060 | ENSP00000349396 | NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity | ATP-binding cassette sub-family D member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm; ATP binding cassette subfamily D | 0.471 |
| NOX3 | FOXI2 | ENSP00000159060 | ENSP00000373572 | NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity | Forkhead box protein I2; Possible transcriptional activator; Forkhead boxes | 0.408 |
| NOX3 | SALL3 | ENSP00000159060 | ENSP00000441823 | NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity | Sal-like protein 3; Probable transcription factor; Zinc fingers C2H2-type | 0.646 |
| OTX2 | SALL3 | ENSP00000343819 | ENSP00000441823 | Homeobox protein OTX2; Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS)- 5’-TCTAATCCC-3’; Belongs to the paired homeobox family. Bicoid subfamily | Sal-like protein 3; Probable transcription factor; Zinc fingers C2H2-type | 0.490 |
| OTX2 | SOX2 | ENSP00000343819 | ENSP00000323588 | Homeobox protein OTX2; Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS)- 5’-TCTAATCCC-3’; Belongs to the paired homeobox family. Bicoid subfamily | Transcription factor SOX-2; Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By si [...] | 0.851 |
| SALL1 | SALL3 | ENSP00000251020 | ENSP00000441823 | Sal-like protein 1; Transcriptional repressor involved in organogenesis; Zinc fingers C2H2-type | Sal-like protein 3; Probable transcription factor; Zinc fingers C2H2-type | 0.614 |
| SALL1 | SOX2 | ENSP00000251020 | ENSP00000323588 | Sal-like protein 1; Transcriptional repressor involved in organogenesis; Zinc fingers C2H2-type | Transcription factor SOX-2; Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By si [...] | 0.966 |
| SALL3 | ABCD4 | ENSP00000441823 | ENSP00000349396 | Sal-like protein 3; Probable transcription factor; Zinc fingers C2H2-type | ATP-binding cassette sub-family D member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm; ATP binding cassette subfamily D | 0.657 |
| SALL3 | CD38 | ENSP00000441823 | ENSP00000226279 | Sal-like protein 3; Probable transcription factor; Zinc fingers C2H2-type | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system; Belongs to the ADP-ribosyl cyclase family | 0.641 |
