node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CACTIN | CXorf56 | ENSP00000415078 | ENSP00000441786 | Cactin; Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing; Belongs to the CACTIN family | UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex | 0.712 |
CXorf56 | CACTIN | ENSP00000441786 | ENSP00000415078 | UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex | Cactin; Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing; Belongs to the CACTIN family | 0.712 |
CXorf56 | ENSG00000249967 | ENSP00000441786 | ENSP00000359683 | UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex | Uncharacterized protein; Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein | 0.670 |
CXorf56 | NHP2L1 | ENSP00000441786 | ENSP00000383949 | UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex | NHP2-like protein 1; Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | 0.626 |
CXorf56 | PDXDC1 | ENSP00000441786 | ENSP00000379691 | UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex | Pyridoxal-dependent decarboxylase domain-containing protein 1; Pyridoxal dependent decarboxylase domain containing 1; Belongs to the group II decarboxylase family | 0.682 |
CXorf56 | RBM4 | ENSP00000441786 | ENSP00000386894 | UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex | RNA-binding protein 4; RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5’-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation [...] | 0.578 |
CXorf56 | SLC25A43 | ENSP00000441786 | ENSP00000217909 | UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex | Solute carrier family 25 member 43; Belongs to the mitochondrial carrier (TC 2.A.29) family | 0.636 |
CXorf56 | SNW1 | ENSP00000441786 | ENSP00000261531 | UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex | SNW domain-containing protein 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coac [...] | 0.742 |
CXorf56 | UBE2A | ENSP00000441786 | ENSP00000360613 | UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex | Ubiquitin-conjugating enzyme E2 A; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at ’Lys-120’ to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes ’Lys-11’, as well as ’Lys-48’-linked polyubiquitination. Requir [...] | 0.664 |
CXorf56 | WDR27 | ENSP00000441786 | ENSP00000416289 | UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex | WD repeat-containing protein 27; WD repeat domain containing | 0.718 |
CXorf56 | WRB | ENSP00000441786 | ENSP00000327716 | UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex | Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane; Belongs to the WRB/GET1 family | 0.678 |
ENSG00000249967 | CXorf56 | ENSP00000359683 | ENSP00000441786 | Uncharacterized protein; Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein | UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex | 0.670 |
NHP2L1 | CXorf56 | ENSP00000383949 | ENSP00000441786 | NHP2-like protein 1; Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex | 0.626 |
NHP2L1 | PDXDC1 | ENSP00000383949 | ENSP00000379691 | NHP2-like protein 1; Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | Pyridoxal-dependent decarboxylase domain-containing protein 1; Pyridoxal dependent decarboxylase domain containing 1; Belongs to the group II decarboxylase family | 0.565 |
NHP2L1 | SNW1 | ENSP00000383949 | ENSP00000261531 | NHP2-like protein 1; Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | SNW domain-containing protein 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coac [...] | 0.985 |
NHP2L1 | WDR27 | ENSP00000383949 | ENSP00000416289 | NHP2-like protein 1; Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | WD repeat-containing protein 27; WD repeat domain containing | 0.618 |
NHP2L1 | WRB | ENSP00000383949 | ENSP00000327716 | NHP2-like protein 1; Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane; Belongs to the WRB/GET1 family | 0.607 |
PDXDC1 | CXorf56 | ENSP00000379691 | ENSP00000441786 | Pyridoxal-dependent decarboxylase domain-containing protein 1; Pyridoxal dependent decarboxylase domain containing 1; Belongs to the group II decarboxylase family | UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex | 0.682 |
PDXDC1 | NHP2L1 | ENSP00000379691 | ENSP00000383949 | Pyridoxal-dependent decarboxylase domain-containing protein 1; Pyridoxal dependent decarboxylase domain containing 1; Belongs to the group II decarboxylase family | NHP2-like protein 1; Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | 0.565 |
PDXDC1 | WDR27 | ENSP00000379691 | ENSP00000416289 | Pyridoxal-dependent decarboxylase domain-containing protein 1; Pyridoxal dependent decarboxylase domain containing 1; Belongs to the group II decarboxylase family | WD repeat-containing protein 27; WD repeat domain containing | 0.689 |