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  • 11.0 [archived version]
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ENSG00000249967 ENSG00000249967 CACTIN CACTIN RBM4 RBM4 WDR27 WDR27 PDXDC1 PDXDC1 CXorf56 CXorf56 WRB WRB NHP2L1 NHP2L1 SLC25A43 SLC25A43 SNW1 SNW1 UBE2A UBE2A
"CXorf56" - UPF0428 protein CXorf56 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CXorf56UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex (208 aa)    
Predicted Functional Partners:
SNW1
SNW domain-containing protein 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coac [...] (536 aa)
     
      0.742
WDR27
WD repeat-containing protein 27; WD repeat domain containing (895 aa)
     
   
  0.718
CACTIN
Cactin; Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing; Belongs to the CACTIN family (758 aa)
     
 
  0.712
PDXDC1
Pyridoxal-dependent decarboxylase domain-containing protein 1; Pyridoxal dependent decarboxylase domain containing 1; Belongs to the group II decarboxylase family (788 aa)
     
   
  0.682
WRB
Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane; Belongs to the WRB/GET1 family (174 aa)
           
  0.678
ENSG00000249967
Uncharacterized protein; Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein (449 aa)
           
  0.670
UBE2A
Ubiquitin-conjugating enzyme E2 A; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at ’Lys-120’ to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes ’Lys-11’, as well as ’Lys-48’-linked polyubiquitination. Requir [...] (152 aa)
     
   
  0.664
SLC25A43
Solute carrier family 25 member 43; Belongs to the mitochondrial carrier (TC 2.A.29) family (341 aa)
     
   
  0.636
NHP2L1
NHP2-like protein 1; Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (128 aa)
     
   
  0.626
RBM4
RNA-binding protein 4; RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5’-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation [...] (364 aa)
     
      0.578
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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